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Volume 10, Number 10—October 2004
Research

Disease Susceptibility to ST11 Complex Meningococci Bearing Serogroup C or W135 Polysaccharide Capsules, North America1

Andrew J. Pollard*Comments to Author , Jan Ochnio†, Margaret Ho†, Martin Callaghan*, Mark Bigham‡, and Simon Dobson†
Author affiliations: Susceptibility to ST11 Complex Meningococci; *University of Oxford, Oxford, United Kingdom; †University of British Columbia, Vancouver, Canada; ‡Canadian Blood Services, Vancouver, Canada

Main Article

Table

Serum bactericidal activity against target strains of Neisseria meningitidis a for serum samples from different age groupsb

Serogroup C (ST11)
Serogroup W135 (ST11)
 Age n GMSBAT 95% CI % >1:8 n GMSBAT 95% CI % >1:8
2 mo 24 2.4 2.3–2.7 4
18 mo 25 2.1 2.1–2.3 4 25 4.3 3.8–5.0 20
4–6 y 25 2 2.0–2.0 0 25 8 6.6–9.7 28
11–12 y 25 2.4 2.2–2.5 4 25 16.5 13.4–20.1 44
16–18 y 25 2.3 2.2–2.4 4 25 24.3 19.4–30.3 44
19–29 y 24 4 3.5–4.6 17 7 21.5 8.1–57.2 43
>30 y 27 7 5.8–8.6 22 18 19.3 13.8–27.3 44

aAOBZ1379(c) (the outbreak clinical isolate from British Columbia) or Z1582/FC978 (a Canadian clinical isolate from 2000 bearing the W135 capsule).
bGMSBAT, geometric mean serum bactericidal assay titers; CI, confidence interval.

Main Article

1These data were partially presented as a poster at the International Pathogenic Neisseria Conference in Oslo, Norway, 2002.

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