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Volume 10, Number 11—November 2004

Research

Histopathologic Improvement with Lymphedema Management, Léogâne, Haiti

Susan F. Wilson*, Jeannette Guarner*, Alix L. Valme†, Jacky Louis-Charles†, Tara L. Jones*, and David G. Addiss*Comments to Author 
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †Hôpital Ste. Croix, Léogâne, Haiti

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Table 3

Number and percentage of skin biopsy specimens in which histopathologic features were detected in 27 patients practicing lymphedema management, Léogâne, Haitia

Location in skin Histopathologic characteristic 1st biopsy (N = 27) n (%) 2nd biopsy (N = 27) n (%) p value
Epidermis Hyperkeratosis 14 (52) 12 (44) 0.59
Hypergranulosis 5 (18) 1 (4) 0.09
Acanthosis 7 (26) 3 (11) 0.16
Superficial dermis Fibrolamellar hyperplasia 16 (59) 11 (41) 0.18
Condensed collagen 10 (37) 5 (18) 0.13
Perivascular fibrosis 4 (15) 1 (4) 0.17
Perivascular infiltrate
   Acute 0 (0) 0 (0)
   Chronic 27 (100) 16 (59) 0.0002
   Pronounced intensity 10 (37) 3 (11) 0.03
   Presence of plasma cells 7 (26) 4 (15) 0.31
Deep dermis Perivascular fibrosis 14 (52) 6 (22) 0.02
Perivascular infiltrate
   Acute 0 (0) 0 (0)
   Chronic 25 (93) 21 (78) 0.12
   Pronounced intensity 9 (33) 6 (22) 0.37
   Presence of plasma cells 18 (67) 18 (67) 1
Periadnexal infiltrate
   Acute 0 (0) 0 (0)
   Chronic 19 (70) 9 (33) 0.007
   Pronounced intensity 7 (26) 0 (0) 0.005
Subcutaneous tissue Infiltrate in fibrous septa
   Acute 0 (0) 0 (0)
   Chronic 10 (37) 10 (37) 1
   Pronounced intensity 5 (18) 1 (4) 0.09

aFor each patient, the second biopsy specimen was taken near the same site on the same lymphedematous leg ≈1 year after the first biopsy.

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