Experimental Everglades Virus Infection of Cotton Rats (Sigmodon hispidus)
Figure 4. Brainstem section of sham-inoculated control rat, showing the absence of an inflammatory response (A). Vascular and perivascular infiltration of mononuclear cells within the brainstem of a Florida cotton rat 7 days after infection with 3.2 log10 PFU/mL EVEV strain FE4-71k; inset enlarged to show cell infiltration (B). Cortex of cotton rat 5 weeks after infection, showing absence of inflammatory response (C). Animals in panels A and B were anesthetized with pentobarbital and perfused with phosphate-buffered saline intracardially. The rat in panel C was not perfused.