Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

Volume 10, Number 12—December 2004

Dispatch

Genome Sequence and Attenuating Mutations in West Nile Virus Isolate from Mexico

David W.C. Beasley*Comments to Author , C. Todd Davis*, Jose Estrada-Franco*, Roberto Navarro-Lopez†, Arturo Campomanes-Cortes†, Robert B. Tesh*, Scott C. Weaver*, and Alan D.T. Barrett*
Author affiliations: *University of Texas Medical Branch, Galveston, Texas, USA; †Comision Mexico-Estados Unidos para la Prevencion de la Fiebre Aftosa y Otras Enfermedades Exoticas de los Animales, Mexico City, Mexico

Main Article

Table 1

Summary of nucleotide and amino acid differences between West Nile virus strains NY99 (AF196835), NY00-grouse3282 (AF404755), and TM171-03a

Nucleotide 
(amino acid) NY99 NY00 TM171-03
50 A A G
71 A A G
93 C T C
381 C C T
483 C C T
858 C C T
887 (prM-141) T (Ile) T (Ile) C (Thr)
1137 C C T
1285 C T C
1432 (E-156)b T (Ser) T (Ser) C (Pro)
1626 C C T
2328 C C T
2388 C C T
2466 C C T
2607 T T C
2832 T T C
2865 C C T
3111 G G A
4146 A G G
4212 T T A
4564 T C C
4749 C C T
6120 C C T
6138 C T T
6141 C C T
6279 G G A
6426 C T T
6495 G G A
6771 A G G
7015 T C C
7359 C C T
7648 (NS4B-245) A (Ile) A (Ile) G (Val)
7672 C C T
7938 T C C
8067 A G A
8109 C C T
8676 A A G
8811 T C C
8838 T T C
8994 T T C
9378 T T C
9408 T T C
9453 C C T
10317 C C T
10373 (NS5-898) C (Thr) C (Thr) T (Ile)
10393 C T T
10828 T T G
10851 A G G
10989 G G A

aBold text indicates residues at which NY00-grouse 3282 and TM171-03 both differed from NY99.
bStrain TM171-03 had a mixed sequence at this residue. Consensus sequence of early passage material had “C” at nucleotide 1432.

Main Article

TOP