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Volume 10, Number 3—March 2004

Dispatch

Endemic Carbapenem-resistant Pseudomonas aeruginosa with Acquired Metallo-β-lactamase Determinants in European Hospital

Cristina Lagatolla*Comments to Author , Enrico A. Tonin*, Carlo Monti-Bragadin*, Lucilla Dolzani*, Francesca Gombac*, Claudia Bearzi*, Elisabetta Edalucci*, Fabrizia Gionechetti*, and Gian Maria Rossolini†
Author affiliations: *Università di Trieste, Trieste, Italy; †Università di Siena, Siena, Italy

Main Article

Table 2

Antimicrobial susceptibility of the 89 imipenem-resistant Pseudomonas aeruginosa isolatesa

Drug resistance profileb blaVIM status
blaVIM-1 
(n = 54) (%) blaVIM-2 
(n = 10) (%) blaVIM-negative 
(n = 25) (%)
Imi
Mem
Caz
Pip
Atm
Ak
Gm
Tob
Cip
39 (72)
10 (100)
7 (28)
Imi
Mem
Caz
Pip
Atm

Gm
Tob
Cip
11 (20)
-
6 (24)
Imi
Mem
Caz
Pip


Gm
Tob
Cip
1 (2)
-
1 (4)
Imi
Mem
Caz
Pip

Ak
Gm
Tob
Cip
2 (4)
-
-
Imi
Mem
Caz


Ak
Gm
Tob
Cip
1 (2)
-
-
Otherc - - 11 (44)

aAll isolates were susceptible to polymixin B. The percentage of isolates resistant to all the tested drugs (except polymixin B) was significantly higher among blaVIM-positive isolates (76 vs. 28%; p < 0.001, according to the χ2 test).
bImi, imipenem; Mem, meropenem; Caz, ceftazidime; Pip, piperacillin; Atm, aztreonam; Ak, amikacin; Gm, gentamicin; Tob, tobramycin; Cip, ciprofloxacin.
cStrains resistant to fewer than 5 antibiotics.

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