TY - JOUR AU - Lagatolla, Cristina AU - Tonin, Enrico A. AU - Monti-Bragadin, Carlo AU - Dolzani, Lucilla AU - Gombac, Francesca AU - Bearzi, Claudia AU - Edalucci, Elisabetta AU - Gionechetti, Fabrizia AU - Rossolini, Gian Maria T1 - Endemic Carbapenem-resistant Pseudomonas aeruginosa with Acquired Metallo-β-lactamase Determinants in European Hospital T2 - Emerging Infectious Disease journal PY - 2004 VL - 10 IS - 3 SP - 535 SN - 1080-6059 AB - Acquired metallo-β-lactamases (MBLs) can confer broad-spectrum β-lactam resistance (including carbapenems) not reversible by conventional β-lactamase inhibitors and are emerging resistance determinants of remarkable clinical importance. In 2001, multidrug-resistant Pseudomonas aeruginosa carrying blaVIM MBL genes were found to be widespread (approximately 20% of all P. aeruginosa isolates and 70% of the carbapenem-resistant isolates) at Trieste University Hospital. Clonal diversity and heterogeneity of resistance determinants (either blaVIM-1-like or blaVIM-2-like) were detected among MBL producers. This evidence is the first that acquired MBLs can rapidly emerge and establish a condition of endemicity in certain epidemiologic settings. KW - Pseudomonas aeruginosa KW - carbapenem-hydrolyzing beta-lactamase KW - drug resistance KW - multiple KW - bacterial KW - bacterial typing KW - hospital infection KW - Italy DO - 10.3201/eid1003.020799 UR - https://wwwnc.cdc.gov/eid/article/10/3/02-0799_article ER - End of Reference