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Volume 10, Number 3—March 2004

Dispatch

Neisseria meningitidis C:2b:P1.2,5 with Intermediate Resistance to Penicillin, Portugal

Manuela Caniça*Comments to Author , Ricardo Dias*, Eugénia Ferreira*, and Meningococci Study Group
Author affiliations: *National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal

Main Article

Table

Distribution of 109 invasive meningococcal isolates by serogroup, serotype, serosubtype and susceptibility to penicillin

Serogroup (no. of strains) Serotype (no. of strains) Serotype: subtypea No. of strains (%) Penicillin susceptibility
No. of strains with the same phenotype in 1995–1999b,c
MIC (μg/mL) S, IRb
B (n = 52)
1 (n = 12)
1:NST
6 (11.6)
0.06
S

1:P1.13
2 (3.8)
0.06
S

1:P1.14
1 (1.9)
0.06
S

1:P1.15
1 (1.9)
0.25
IR

1:P1.4
1 (1.9)
0.06
S

1:P1.9
1 (1.9)
0.06
S

2b (n = 1)
2b:NST
1 (1.9)
0.06
S

4 (n = 16)
4:P1.2,5
2 (3.8)
0.06
S


1 (1.9)
0.125
IR

4:P1.4
3 (5.8)
0.06
S

4:P1.6
1 (1.9)
0.06
S

4:P1.14
1 (1.9)
0.06
S
1 (IR)
4:P1.15
5 (9.6)
0.06
S
1 (S)

2 (3.8)
0.125
IR

4:NST
1 (1.9)
0.06
S

14 (n = 2)
14:NST
1 (1.9)
0.06
S
3 (S)
14:P1.12
1 (1.9)
0.25
IR

15 (n = 6)
15:P1.7
1 (1.9)
0.06
S

15:P1.7,16
5 (9.6)
0.06
S
5 (S)
NT (n = 15)
NT:P1.2,5
1 (1.9)
0.06
S

NT:P1.6
1 (1.9)
0.06
S
2 (S)
NT:P1.7,16
1 (1.9)
0.06
S
1 (IR)
NT:P1.9
5 (9.6)
0.06
S
1 (S)
NT:P1.12
1 (1.9)
0.06
S

NT:P1.15
2 (3.8)
0.06
S
1 (S)
1 (1.9)
0.25
IR

NT:NST
3 (5.8)
0.06
S
1 (IR)
C (n = 54)
2a (n = 2)
2a:P1.2,5
1 (1.9)
0.06
S
2 (S)
2a:P1.5
1 (1.9)
0.06
S

2b (n = 48)
2b:P1.2
2 (3.7)
0.06
S
1 (IR)
1 (1.9)
0.125
IR

1 (1.9)
0.25
IR

2b:P1.2,5
11 (20.4)
0.06
S
18 (3 S, 15 IR)
10 (18.5)
0.125
IR

18 (33.3)
0.25
IR

2 (3.7)
0.5
IR

2b:P1.5
1 (1.9)
0.06
S
1 (IR)
2b:NST
1 (1.9)
0.25
IR
1 (IR)
1 (1.9)
15 (n = 1)
15:NST
1 (1.9)
0.5
IR

0.06
S

NT (n = 3)
NT:P1.2,5
1 (1.9)
0.06
S

NT:P1.5
1 (1.9)
0.06
S

NT:NST
1 (1.9)
0.06
S

W135 (n = 3) 2a (n = 3) 2a:P1.2,5 2 (66.7)
0.06
S
4 (3S, 1IR)
1 (33.3) 0.125 IR

aNT, non-serotypable; NST, non-serosubtypeable.
bS, susceptible; IR, intermediate resistance.
cPhenotypes that already existed in a strain collection isolated in nine Portuguese hospitals from January 1995 to December 1999 (n = 54) (8). Phenotypes present in the earlier collection not found in our study (unpub. data) are: B:2b:P1.5, B:4:P1.7, B:15:P1.9, B:15:P1.13, B:15:NST, B:NT:P1.14, B:NT:P1.16, C:2a:P1.14, C:2a:NST, C:4:P1.12; W135:NT:NST (n = 1 for each phenotype).

Main Article

1The hospitals and principal collaborators who participated in the Meningococci Study Group were: Hospital Dr. José Maria Grande, Portalegre (V. Inês, F. Pádua); Hospital José Joaquim Fernandes, Beja (F. Furtado, R. Bento); Hospital de Setúbal (T. Gouveia); Hospital Nossa Senhora do Rosário, Barreiro (M. Henriques, A. Jesus); Hospital Garcia de Orta, Almada (P. Azeredo, M.J. Águas, J. Diogo); Hospital Militar de Belém, Lisboa (M.T. Cabral); Hospital de Santa Maria, Lisboa (P. Valente, J. Neves, M.J. Salgado); Hospital S. Francisco Xavier, Lisboa (A. Neto, C. Lemos, F. Martins); Hospital de Dona Estefânia, Lisboa (L. Carvalho, R. Barros); Hospital Fernando Fonseca, Amadora (M.J. Brito, L. Sancho); Hospital Conde de Castro Guimarães, Cascais (M. Martins, A. Coutinho); Hospital Reynaldo dos Santos, Vila Franca de Xira (I. Fonseca, C. Tonel, M. Vasconcelos); Hospital Pediátrico-CHC, Coimbra (L. Januário); Hospital Geral dos Covões-CHC (M.J. Faria); Centro Hospitalar das Caldas da Rainha, Caldas da Rainha (C. Duarte, J. Pinto); Hospital de São Teotónio, Viseu (G. Figueiredo, L. Simões, J. Ribeiro); Hospital Padre Américo, Vale de Sousa (A. Oliveira, F. Assunção); Hospital Distrital de Aveiro, Aveiro (J. Roseta); Hospital Eduardo Santos Silva, Vila Nova de Gaia (E. Alves, P. Lopes); Hospital Geral de Santo António, Porto (J. Monteiro, J. Amorim); Hospital Joaquim Urbano, Porto (A. Horta); Hospital Distrital de Bragança, Bragança (J. Marques); Hospital S. Pedro de Vila Real, Vila Real (A. Pereira, A. Castro); Hospital Distrital de Chaves, Chaves (J. Morais); Hospital de Santa Luzia, Viana do Castelo (M. de Melo, A. Martinez); Hospital do Divino Espírito Santo, Ponta Delgada, Açores (C. Macedo, M. Mota, E. Carvalho); Centro Hospitalar do Funchal, Funchal, Madeira (M. Freitas, T. Afonso).

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