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Volume 10, Number 4—April 2004

Research

Pneumocystis jiroveci Dihydropteroate Synthase Genotypes in Immunocompetent Infants and Immunosuppressed Adults, Amiens, France

Anne Totet*, Sophie Latouche†, Philippe Lacube†, Jean-Claude Pautard*, Vincent Jounieaux*, Christian Raccurt*, Patricia Roux†, and Gilles Nevez*Comments to Author 
Author affiliations: *University Hospital, University of Picardy, Amiens, France; †Saint-Antoine University Hospital, Paris, France

Main Article

Table 2

Pneumocystis jiroveci dihydropteroate synthase (DHPS) genotypes in immunocompetent infants with mild infection and in immunosuppressed adults with Pneumocystis pneumonia, University Hospital of Amiens, France

DHPS genotype Nucleotide at position (amino acid at position)
Infants Adults
165 (55) 171 (57)
Wild genotypea
A (Thr)
C (Pro)
30
12

A (Thr)
T (Ser)
b

Double mutant genotypea
G (Ala)
T (Ser)


Wild genotype + mutant genotypec
A/G (Thr/Ala)
C (Pro)
1

Wild genotype + mutant genotyped
A (Thr)
C/T (Pro/Ser)
2
1
Wild genotype + double mutant genotypee
A/G (Thr/Ala)
C/T (Pro/Ser)


Undetermined genotype 12f

aInfection with a single genotype.
b–, absence.
c, d, e Mixed infections related to the association of a wild genotype with a mutant genotype.
cMutant genotype with a mutation at nucleotide position 165 (amino acid position 55).
dMutant genotype with a mutation at nucleotide position 171 (amino acid position 57).
eDouble mutant with both mutations at nucleotide positions 165 and 171.
fAbsence of DHPS amplification despite initial detection by polymerase chain reaction at mtLSUrRNA.

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