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Volume 10, Number 5—May 2004

Dispatch

Mycobacterium africanum Cases, California

Edward Desmond*Comments to Author , Ameena T. Ahmed*, William S. Probert*, Janet Ely*, Yvonne Jang*, Cynthia A. Sanders*, Shou-Yean Lin*, and Jennifer Flood*
Author affiliations: *California Department of Health Services, Berkeley, California

Main Article

Table 2

Phenotypic and molecular characteristics of Mycobacterium africanum isolates and country of birth for five patients

Patient No. of copies of IS6110 (bands) Spoligo-typing pattern missing spacers 8,9,39? OxyR285a Codon katG463 sequenceb Presence of RD9 deletion? PZA susceptibilityc Niacin pro-duction Nitratereduc-tiond Major site of disease Birth country
A
10
Yes
G
CTG
Yes
S
+
3+
Lung
South Africa
B
3
Yes
G
CTG
Yes
S
N.D.e
N.D.
Lung
Ivory Coast
C
9f
Yes
G
CTG
Yes
S
N.D.
N.D.
Lung
South Africa
D
11
Yes
G
CTG
Yes
S
+
4+
Lung
Vietnam
E 9 Yes G CTG Yes S + 3+ Pancreas USA

aIsolates of M. bovis do not have G at this site.
bCTG is found in M. bovis and M. africanum, but not in most strains of M. tuberculosis.
cS, susceptible; PZA, pyrazinamide.
d3+ and 4+ reactions are considered positive.
eND, not done (because the culture lost viability).
fRestriction fragment length polymorphism patterns for isolates from patients C and E were identical.

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