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Volume 10, Number 5—May 2004
Research

Virulence Factors for Hemolytic Uremic Syndrome, Denmark1

Steen Ethelberg*Comments to Author , Katharina E. P. Olsen*, Flemming Scheutz*†, Charlotte Jensen*, Peter Schiellerup*, Jørgen Engberg*, Andreas Munk Petersen*, Bente Olesen*, Peter Gerner-Smidt*, and Kåre Mølbak*
Author affiliations: *Statens Serum Institut, Copenhagen, Denmark; †The World Health Organization International Escherichia Centre, Copenhagen, Denmark

Main Article

Table 3

Risk factors for HUS among 343 STEC patients, Denmark, 1997–2003a

Univariate analysis Multivariate analysis
Determinant
No. of patients
No. (%) with HUS
OR
95% CI
OR
95% CI
eae
Negative
111
0
1



Positive
232
21 (9.1)
NDb

NI

stx2












Negative
159
1 (0.6)
1

1

Positive
184
20 (10.9)
19.3
2.6 to 145
18.9
2.4 to 146
Age
>8 y
178
3 (1.7)
1

1

<7 y
165
18 (10.9)
7.5
2.2 to 26.0
11.4
3.2 to 41.3
Bloody diarrhea
No
218
6 (2.8)
1

1

Yes
125
15 (12.0)
4.8
1.8 to 12.8
4.5
1.6 to 12.7
O157
No
262
10 (3.8)
1



Yes
81
11 (13.6)
4.0
1.6 to 9.7
NS

O111
No
337
19 (5.6)
1



Yes 6 2 (33.3) 8.4 1.4 to 48.6 NS

aSTEC, Shiga toxin–producing Escherichia coli; HUS, hemolytic uremic syndrome; OR, odds ratio; CI, confidence intervals; NI, not included (test not appropriate); ND, not defined; NS, not statistically significant.
bp < 0.0002, Fisher exact test.

Main Article

1Presented in part at the VTEC2003, 5th International Symposium on “Shiga Toxin (Verocytotoxin) Producing Escherichia coli Infections,” Edinburgh, Scotland, June 2003 (abstract O-6).

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