TY - JOUR AU - Ethelberg, Steen AU - Olsen, Katharina E. P. AU - Scheutz, Flemming AU - Jensen, Charlotte AU - Schiellerup, Peter AU - Engberg, Jørgen AU - Petersen, Andreas Munk AU - Olesen, Bente AU - Gerner-Smidt, Peter AU - Mølbak, Kåre T1 - Virulence Factors for Hemolytic Uremic Syndrome, Denmark T2 - Emerging Infectious Disease journal PY - 2004 VL - 10 IS - 5 SP - 842 SN - 1080-6059 AB - We present an analysis of strain and patient factors associated with the development of bloody diarrhea and hemolytic uremic syndrome (HUS) among Shiga toxin-producing Escherichia coli (STEC) patients registered in Denmark in a 6-year period. Of 343 STEC patients, bloody diarrhea developed in 36.4% and HUS in 6.1%. In a multivariate logistic regression model, risk factors for bloody diarrhea were the eae and stx2 genes, O groups O157 and O103, and increasing age. Risk factors for HUS were presence of the stx2 (odds ratio [OR] 18.9) and eae (OR undefined) genes, being a child, and having bloody diarrhea. O group O157, although associated with HUS in a univariate analysis (OR 4.0), was not associated in the multivariate analysis (OR 1.1). This finding indicates that, rather than O group, the combined presence of the eae and stx2 genes is an important predictor of HUS. KW - Escherichia coli O157 KW - Verocytotoxin KW - Stx Protein KW - Antibiotics KW - Cohort Analysis KW - Virulence Factor KW - Epidemiology KW - Serotype KW - Denmark DO - 10.3201/eid1005.030576 UR - https://wwwnc.cdc.gov/eid/article/10/5/03-0576_article ER - End of Reference