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Volume 10, Number 5—May 2004

Research

Multidrug-resistant Tuberculosis in Central Asia

Helen Suzanne Cox*Comments to Author , Juan Daniel Orozco*, Roy Male*, Sabine Ruesch-Gerdes†, Dennis Falzon*, Ian Small*, Darebay Doshetov‡, Yared Kebede§, and Mohammed Aziz¶
Author affiliations: *Médecins Sans Frontières Aral Sea Area Programme, Uzbekistan and Turkmenistan, Tashkent, Uzbekistan; †National Reference Centre for Mycobacteria, Borstel, Germany; ‡Ministry of Health, Nukus, Karakalpakstan, Uzbekistan; §Médecins Sans Frontières, Amsterdam, the Netherlands; ¶World Health Organization, Geneva, Switzerland

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Table 2

First-line anti-tuberculosis drug resistance results, Karakalpakstan, Uzbekistana

No. new cases (%) No. retreatment cases (%) Total no. (%)
Total tested 106 107 213
Any resistance 51 (48.1) 86 (80.4) 137 (64.3)
Monoresistance
H only 3 (2.8) 7 (6.5) 10 (4.7)
R only 0 0 0
E only 0 0 0
S only 12 (11.3) 11 (10.3) 23 (10.8)
Z only 0 1 (0.9) 1 (0.5)
H and R resistance
MDR 14 (13.2) 43 (40.2) 57 (26.8)
HR only 0 1 (0.9) 1 (0.5)
HRE only 0 0 0
HRS only 4 (3.8) 10 (9.3) 14 (6.6)
HRZ only 0 0 0
HRES only 6 (5.7) 19 (17.8) 25 (11.7)
HREZ only 0 0 0
HRSZ only 1 (0.9) 0 1 (0.5)
HRESZ 3 (2.8) 13 (12.1) 16 (7.5)
H + other resistance
HE only 0 0 0
HS only 13 (12.3) 15 (14.0) 28 (13.1)
HZ only 1 (0.9) 1 2 (0.9)
HES only 2 (1.9) 4 (3.7) 6 (2.8)
HEZ only 0 0 0
HSZ only 1 (.9) 3 (2.8) 4 (1.9)
HESZ only 5 (4.7) 1 (0.9) 6 (2.8)
R + other resistance
RE only 0 0 0
RS only 0 0 0
RZ only 0 0 0
RES only 0 0 0
RESZ only 0 0 0
Any drug resistance
Any H resistance 39 (36.8) 74 (69.2) 113 (53.1)
Any R resistance 14 (13.2) 43 (40.2) 57 (26.8)
Any E resistance 16 (15.1) 37 (34.6) 53 (24.9)
Any S resistance 47 (44.3) 76 (71.0) 123 (57.7)
Any Z resistance 11 (10.4) 19 (17.8) 30 (14.1)

aH, isoniazid; R, rifampin; E, ethambutol; S, streptomycin; Z, pyrizinamide.

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