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Volume 10, Number 5—May 2004

Research

Genetic Variation of SARS Coronavirus in Beijing Hospital

Dongping Xu*, Zheng Zhang*, Fuliang Chu*, Yonggang Li*, Lei Jin*, Lingxia Zhang*, George F. Gao†, and Fu-Sheng Wang*Comments to Author 
Author affiliations: *Beijing 302 Hospital, Beijing, China; †University of Oxford, Headington, Oxford, United Kingdom

Main Article

Table 2

Variation in S-gene sequences from 20 individual SARS patientsa,b

Pt. no. Samp. no. 21494
21702
21858
22908
23198
24018
24247
24469
24540
C→T A→G A→T A→G T→C A→T T→C A→G A→G
1
SW6









2
SW17
9/2c
+




+


3
PL1
8/39
8/43
48/2
+
+
+
+
+
+
4
PL10
14/7
+

+
+
2/8
+
+
+

PL17
+
+



+
+
+
+

SP4

+

+

+
+
+
+
5
PL9
+
+

+
+
+
+
+
+

SP1

+

+
+

+
+
+
6
PL5

+

+
+
8/4
+
+
+

SP9

+

+
+
+
+
+
+
7
PL7

+

+
+
4/6
+
+
+
8
PL8
7/28
+
33/2
+
+
+
+
+
+
9
SP15

+








SP32

+







10
SP6










SP62










SW73









11
SP67

+







12
SW76

+







13
ST123

+







14
PL57

+


+
+
+
+
+

SW77

+


+
+
+
+
+
15
SP61

+







16
PL59









17
SP28

+







18
SP43

+







19
ST158

+

+
+
+
+
+
+

SP13
19/4
14/10
10/13
+
+
+
6/16
+
14/8
20 SP8 +

aThe results were determined by analysis of cloned sequences; + represents that nucleotide substitution at the variant site is detected and – represents that the nucleotide at the site is identical to the one of BJ01 reference sequence in all analyzed sequences.
bSARS, severe acute respiratory syndrome; SW, throat swab; PL, plasma; SP, sputum; ST, stool.
cThe numbers represent the ratio of reference to variant nucleotide detected at the site from the analyzed cloned sequences.

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