TY - JOUR AU - Duck, William M. AU - Sobel, Jeremy AU - Pruckler, Janet M. AU - Song, Qunsheng AU - Swerdlow, David AU - Friedman, Cindy AU - Sulka, Alana AU - Swaminathan, Balasubra AU - Taylor, Tom AU - Hoekstra, Mike AU - Griffin, Patricia AU - Smoot, Duane AU - Peek, Rick AU - Metz, DavidC. AU - Bloom, Peter B. AU - Goldschmid, Steven AU - Parsonnet, Julie AU - Triadafilopoulos, George AU - Perez-Perez, Guillermo I. AU - Vakil, Nimish AU - Ernst, Peter AU - Czinn, Steve AU - Dunne, Donald AU - Gold, Ben D. T1 - Antimicrobial Resistance Incidence and Risk Factors among Helicobacter pylori–Infected Persons, United States T2 - Emerging Infectious Disease journal PY - 2004 VL - 10 IS - 6 SP - 1088 SN - 1080-6059 AB - Helicobacter pylori is the primary cause of peptic ulcer disease and an etiologic agent in the development of gastric cancer. H. pylori infection is curable with regimens of multiple antimicrobial agents, and antimicrobial resistance is a leading cause of treatment failure. The Helicobacter pylori Antimicrobial Resistance Monitoring Program (HARP) is a prospective, multicenter U.S. network that tracks national prevalence rates of H. pylori antimicrobial resistance. Of 347 clinical H. pylori isolates collected from December 1998 through 2002, 101 (29.1%) were resistant to one antimicrobial agent, and 17 (4.8%) were resistant to two or more antimicrobial agents. Eighty-seven (25.1%) isolates were resistant to metronidazole, 45 (12.9%) to clarithromycin, and 3 (0.9%) to amoxicillin. On multivariate analysis, black race was the only significant risk factor (p < 0.01, hazard ratio 2.04) for infection with a resistant H. pylori strain. Formulating pretreatment screening strategies or providing alternative therapeutic regimens for high-risk populations may be important for future clinical practice. KW - Helicobacter pylori KW - antimicrobial resistance KW - risk factors KW - United States DO - 10.3201/eid1006.030744 UR - https://wwwnc.cdc.gov/eid/article/10/6/03-0744_article ER - End of Reference