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Volume 10, Number 7—July 2004

Research

Fluoroquinolone and Other Antimicrobial Resistance in Invasive Pneumococci, Hong Kong, 1995–2001

Pak-Leung Ho*Comments to Author , Tak-Lun Que†, Susan S. Chiu*, Raymond W. H. Yung†, Tak-Keung Ng§, Dominic N. C. Tsang¶, Wing-Hong Seto*, and Yu-Lung Lau*
Author affiliations: *Queen Mary Hospital, The University of Hong Kong, Hong Kong Special Administrative Region (SAR), China; †Tuen Mun Hospital, Hong Kong SAR, China; ‡Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China; §Princess Margaret Hospital, Hong Kong, SAR, China; ¶Queen Elizabeth Hospital, Hong Kong SAR, China

Main Article

Table 1

MICs of 11 antimicrobial agents for Streptococcus pneumoniae isolates based on susceptibility to penicillina,b

Antimicrobial agent and penicillin susceptibility status
MIC (μg/mL)
% of Isolates

Range
50%
90%
Mode
S
I
R
Penicillin







  All
0.008−4
0.032
2
0.016
62.6
20.0
17.4
  Pen-S
0.008−0.064
0.016
0.032
0.016
100
0.0
0.0
  Pen-I
0.125−1
1
1
1
0.0
100
0.0
  Pen-R
2−4
2
2.0
2
0.0
0.0
100
Amoxicillin







  All
0.016−4
0.032
2
0.016
99.6
0.4
0.0
  Pen-S
0.016−0.125
0.016
0.032
0.016
100.0
0.0
0.0
  Pen-I
0.032−2
1
2
1
100.0
0.0
0.0
  Pen-R
0.5−4
2
2
2
97.8
2.2
0.0
Cefotaxime







  All
0.016−4
0.032
1
0.016
97.0
2.6
0.4
  Pen-S
0.016−0.125
0.016
0.032
0.016
100.0
0.0
0.0
  Pen-I
0.032−2
1
1
1
100.0
0.0
0.0
  Pen-R
0.5−4
1
2
1
82.6
15.2
2.2
Cefepime







  All
0.016−4
0.064
2
0.064
76.2
21.9
1.9
  Pen-S
0.016−0.25
0.064
0.125
0.064
100.0
0.0
0.0
  Pen-I
0.032−1
1
2
2
66.0
34.0
0.0
  Pen-R
1−4
2
2
2
2.2
87
10.9
Clarithromycin







  All
0.032−256
4
256
256
36.6
0.4
63.0
  Pen-S
0.032−256
0.125
256
0.125
56.0
0.0
44.0
  Pen-I
0.064−256
256
256
256
7.5
1.9
90.6
  Pen-R
2−256
4
256
2
0.0
0.0
100.0
Vancomycin







  All
0.25−1
0.5
0.5
0.5
100.0
0.0
0.0
  Pen-S
0.25−1
0.5
0.5
0.5
100.0
0.0
0.0
  Pen-I
0.25−1
0.5
0.5
0.5
100.0
0.0
0.0
  Pen-R
0.25−1
0.5
1
0.5
100.0
0.0
0.0
Ciprofloxacin







  All
0.25−32
1
1
1
95.8

4.2
  Pen-S
0.25−4
1
1
1
99.4

0.6
  Pen-I
0.25−32
1
1
1
94.3

5.7
  Pen-R
0.5−32
1
32
1
84.8

15.2
Levofloxacin







  All
0.125−32
1
1
1
96.2
0.0
3.8
  Pen-S
0.125−2
1
1
1
100.0
0.0
0.0
  Pen-I
0.125−32
1
1
1
94.3
0.0
5.7
  Pen-R
0.5−32
1
32
1
84.8
0.0
15.2
Sparfloxacin







  All
0.125−32
0.25
0.5
0.5
95.8
0.8
3.2
  Pen-S
0.125−1
0.25
0.5
0.5
99.4
0.6
0.0
  Pen-I
0.125−32
0.25
0.5
0.5
94.3
0.0
5.7
  Pen-R
0.25−32
0.5
32
0.5
84.8
2.2
13.0
Gatifloxacin







  All
0.064−16
0.25
0.25
0.25
96.2
0.8
3.0
  Pen-S
0.064−1
0.25
0.25
0.25
100.0
0.0
0.0
  Pen-I
0.125−8
0.25
0.25
0.25
94.3
1.9
3.8
  Pen-R
0.125−16
0.25
8
0.25
84.8
2.2
13.0
Moxifloxacin







  All
0.064−8
0.125
0.25
0.125
97.0
0.8
2.3
  Pen-S
0.064−1
0.125
0.25
0.125
100.0
0.0
0.0
  Pen-I
0.064−4
0.125
0.25
0.125
96.2
1.9
1.9
  Pen-R 0.125−8 0.125 4 0.125 87.0 2.2 10.9

aN = 265; a total of 166 isolates were penicillin-susceptible (Pen-S), 53 were penicillin-intermediate (Pen-I), and 46 were penicillin-resistant (Pen-R).

b50% and 90%, MIC50 and MIC90, respectively.

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