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Volume 10, Number 7—July 2004

Dispatch

Human Metapneumovirus and Severity of Respiratory Syncytial Virus Disease

Isaac Lazar*, Carla Weibel*, James Dziura*, David Ferguson*, Marie L. Landry*, and Jeffrey S. Kahn*Comments to Author 
Author affiliations: *Yale University School of Medicine, New Haven, Connecticut, USA; Co-infection with Human Metapneumovirus

Main Article

Table

Comparison between the group of children admitted to PICU with severe RSV disease and the group of children with mild RSV disease

Characteristic PICUa Non PICUa Statistical comparison (p value)b
Median age (range)
7 wk (2 wk–21 mo)
54 wk (10 d–4 y)
0.025b
Prematurity (%)
5/23 (21.7)
3/23 (13.0)
> 0.1c
RSVd PCR/DFAe (%)
21/23 (91.3)
23/23 (100)
0.244c
Hospitalized (%)
23/23 (100)
8/23 (34.8)
0.004c
Median CSSf (range)
5 (3–6)
1 (0–4)
< 0.001b
PPVg (%)
17/23 (73.9)
0/23 (0)
NDh
RSV/HMPVi co-infection 0/23 (0) 0/23 (0) 1.0

aPICU, Pediatric Intensive Care Unit.
cWilcoxon rank sum test.
bχ2 test.
dRSV, respiratory syncytial virus.
eDFA, direct fluorescent antibody screen.
fCCS, clinical severity score.
gPPV, positive pressure ventilation.
hND, non-comparable as patients requiring PPV are admitted to the PICU.
iHMPV, human metapneumovirus.

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