Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

Volume 10, Number 9—September 2004

Research

Silent Nucleotide Polymorphisms and a Phylogeny for Mycobacterium tuberculosis

Lucy Baker*, Tim Brown*, Martin Maiden†, and Francis Drobniewski*Comments to Author 
Author affiliations: *Heal Protection Agency, London, UK; †University of Oxford, Oxford, UK

Main Article

Table 3

Characteristic features of the four major lineages of Mycobacterium tuberculosis with respect to M. bovis

Species/lineage TbD1 region of difference Silent single nucleotide polymorphism
Nonsynonymous base substitutions
Spoligotype signature spacer deletion
rpoB
3243
T rpoB
2646
G katG
87
A katG
609
T oxyR
285
A oxyR
37
T katG
1388
G ahpC
–46
A
M. tuberculosis Lineage I 1–34
M. tuberculosis Lineage II + + 33–36
M. tuberculosis Lineage III + + 4–8, 23–24
M. tuberculosis Lineage IV + + 29–32 and 34
M. bovis + + + + 39–43

Main Article

TOP