TY - JOUR AU - Muwonge, Apollo AU - Nanyunja, Miriam AU - Rota, Paul AU - Bwogi, Josephine AU - Lowe, Luis AU - Liffick, Stephanie AU - Bellini, William AU - Sylvester, Sempala T1 - New Measles Genotype, Uganda T2 - Emerging Infectious Disease journal PY - 2005 VL - 11 IS - 10 SP - 1522 SN - 1080-6059 AB - We report the first genetic characterization of wildtype measles viruses from Uganda. Thirty-six virus isolates from outbreaks in 6 districts were analyzed from 2000 to 2002. Analyses of sequences of the nucleoprotein (N) and hemagglutinin (H) genes showed that the Ugandan isolates were all closely related, and phylogenetic analysis indicated that these viruses were members of a unique group within clade D. Sequences of the Ugandan viruses were not closely related to any of the World Health Organization reference sequences representing the 22 currently recognized genotypes. The minimum nucleotide divergence between the Ugandan viruses and the most closely related reference strain, genotype D2, was 3.1% for the N gene and 2.6% for the H gene. Therefore, Ugandan viruses should be considered a new, proposed genotype (d10). This new sequence information will expand the utility of molecular epidemiologic techniques for describing measles transmission patterns in eastern Africa. KW - Measles KW - virus KW - isolation KW - sequencing KW - genotype KW - research KW - Uganda DO - 10.3201/eid1110.050431 UR - https://wwwnc.cdc.gov/eid/article/11/10/05-0431_article ER - End of Reference