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Volume 11, Number 10—October 2005

Research

Evolution of H5N1 Avian Influenza Viruses in Asia

The World Health Organization Global Influenza Program Surveillance Network

Main Article

Table 3

Sensitivity of H5N1 influenza isolates to oseltamivir

Virus Oseltamivir IC50*
H1N1 (H274)† 0.69
H1N1 (Y274)† 85.92
H3N2 (R292)‡ 1.99
H3N2 (K292)‡ 1,600.00
Hong Kong/483/97 4.86
Hong Kong/213/03 5.07
Vietnam /1194/04 2.49
Vietnam/1203/04 7.68
Chicken/VN/NCVD1/04 5.87
Chicken/VN/NCVD8/03 9.90

*Median inhibitory concentration (IC50) of oseltamivir (nmol/L) for H5N1 influenza isolates and control H1N1 or H3N2 isolates (results for viruses shown are representatives of 31 isolates tested).
†Wildtype (H274) and resistant mutant (Y274) influenza virus A/Texas/36/91 (H1N1).
‡Wildtype (R292) and resistant mutant (K292) influenza virus A/Victoria/3/75 (H3N2).

Main Article

1Members of the World Health Organization Global Influenza Program and collaborating laboratories: Jean-Thierry Aubin, Saliha Azebi, Amanda Balish, Jill Banks, Niranjan Bhat, Rick A. Bright, Ian Brown, Philippe Buchy, Ana-Maria Burguiere, Hua-lan Chen, Peter Cheng, Nancy J. Cox, Alice Crosier, Aaron Curns, Frédérique Cuvelier, Guohua Deng, Julia Desheva, Stéphanie Desvaux, Nguyen Hong Diep, Ruben O. Donis, Alan Douglas, Scott F. Dowell, Nguyen Tien Dung, Lindsay Edwards, Keiji Fukuda, Rebecca Garten, Elena Govorkova, Victoria Gregory, Alan Hampson, Nguyen Thi Hong Hanh, Scott Harper, Alan Hay, Erich Hoffmann, Diane Hulse, Masaki Imai, Shigeyuki Itamura, Samadhan Jadhao, Patricia Jeannin, Chun Kang, Jackie Katz, Jae-Hong Kim, Alexander Klimov, Yong-kuk Kwon, Chang-Won Lee, Phuong Song Lien, Yanbing Li, Wilina Lim, Yi Pu Lin, Stephen Lindstom, LaMorris Loftin, Jan Mabry, Le Quynh Mai, Taronna Maines, Jean-Claude Manuguerra, Masaji Mase, Yumi Matsuoka, Margaret McCarron, Marie-Jo Medina, Doan Nguyen, Ai Ninomiya, Masatsugu Obuchi, Takato Odagiri, Malik Peiris, Michael L. Perdue, Jean-Marc Reynes, James Robertson, Claudine Rousseaux, Takehiko Saito, Somchai Sangkitporn, Michael Shaw, James M. Simmerman, M. Slomka, Catherine Smith, San Sorn, Erica Spackman, Klaus Stöhr, David L. Suarez, Haan Woo Sung, David E Swayne, Maryse Tardy-Panit, Masato Tashiro, Pranee Thawatsupha, Terrence Tumpey, Timothy Uyeki, Phan Van Tu, Sylvie van der Werf, Sirenda Vong, Richard Webby, Robert Webster, John Wood, Xiyan Xu, Guan Yi, and Wenqing Zhang. For author affiliations, please Download PDF (37 KB, 2 pages).

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