TY - JOUR AU - Wedel, Stephanie AU - Bender, Jeffrey AU - Leano, Fe AU - Boxrud, David AU - Hedberg, Craig AU - Smith, Kirk T1 - Antimicrobial-drug Susceptibility of Human and Animal Salmonella Typhimurium, Minnesota, 1997–2003 T2 - Emerging Infectious Disease journal PY - 2005 VL - 11 IS - 12 SP - 1899 SN - 1080-6059 AB - We compared antimicrobial resistance phenotypes and pulsed-field gel electrophoresis (PFGE) subtypes of 1,028 human and 716 animal Salmonella enterica serotype Typhimurium isolates from Minnesota from 1997 to 2003. Overall, 29% of human isolates were multidrug resistant. Predominant phenotypes included resistance to ampicillin, chloramphenicol or kanamycin, streptomycin, sulfisoxazole, and tetracycline (ACSSuT or AKSSuT). Most human multidrug-resistant isolates belonged to PFGE clonal group A, characterized by ACSSuT resistance (64%), or clonal group B, characterized by AKSSuT resistance (19%). Most animal isolates were from cattle (n = 358) or swine (n = 251). Eighty-one percent were multidrug resistant; of these, 54% were at least resistance phenotype ACSSuT, and 43% were at least AKSSuT. More than 80% of multidrug-resistant isolates had a clonal group A or B subtype. Resistance to ceftriaxone and nalidixic acid increased, primarily among clonal group A/ACSSuT isolates. Clonal group B/AKSSuT isolates decreased over time. These data support the hypothesis that food animals are the primary reservoir of multidrug-resistant S. Typhimurium. KW - Salmonella Typhimurium KW - antimicrobial resistance KW - pulsed-field gel electrophoresis KW - human KW - animal KW - research KW - Minnesota KW - United States DO - 10.3201/eid1112.050158 UR - https://wwwnc.cdc.gov/eid/article/11/12/05-0158_article ER - End of Reference