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Volume 11, Number 2—February 2005

Research

Carbapenemase-producing Enterobacteriaceae, U.S. Rivers

Cécile Aubron*, Laurent Poirel*, Ronald J Ash†, and Patrice Nordmann*Comments to Author 
Author affiliations: *University Paris XI, Paris, France; †Washburn University, Topeka, Kansas, USA

Main Article

Table 2

MICs (mg/L) of β-lactams for several carbapenemase producers and reference strain Escherichia coli DH10B

β-Lactam(s)* Enterobacter asburiae MS7† E. cloacae 1413B† Escherichia coli DH10B (pNat)‡ E. coli DH10B 
(pIMI-2)‡ E. coli DH10B
Amoxicillin >512 >512 >512 >512 4
Amoxicillin + CLA >512 >512 >512 >512 4
Ticarcillin 128 >256 128 256 4
Ticarcillin + CLA 16 >256 16 32 4
Piperacillin 16 >256 8 128 2
Piperacillin + TZB 4 >256 2 16 2
Cephalothin 512 >256 64 512 4
Cefotaxime 0.06 1 0.06 1 0.06
Ceftazidime 0.12 2 0.06 0.5 0.25
Aztreonam 4 8 4 64 0.12
Imipenem >64 >64 16 >64 0.06
Meropenem 32 4 2 32 0.06

*CLA, clavulanic acid at a fixed concentration of 2 mg/L; TZB, tazobactam at a fixed concentration of 4 mg/L.
Enterobacter asburiae MS7 produces acquired β-lactamase IMI-2, whereas E. cloacae 1413B produces acquired β-lactamases TEM-1 and IMI-1 (5).
‡Natural plasmid pNat harbors the blaIMI-2 gene, whereas pIMI-2 is a recombinant plasmid that has the same β-lactamase gene.

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