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Volume 11, Number 2—February 2005

Research

Human Disease from Influenza A (H5N1), Thailand, 2004

Tawee Chotpitayasunondh*, Kumnuan Ungchusak†, Wanna Hanshaoworakul†, Supamit Chunsuthiwat†, Pathom Sawanpanyalert†, Rungruen Kijphati†, Sorasak Lochindarat*, Panida Srisan*, Pongsan Suwan†, Yutthasak Osotthanakorn†, Tanakorn Anantasetagoon†, Supornchai Kanjanawasri†, Sureeporn Tanupattarachai†, Jiranun Weerakul†, Ruangsri Chaiwirattana†, Monthira Maneerattanaporn†, Rapol Poolsavatkitikool†, Kulkunya Chokephaibulkit‡, Anucha Apisarnthanarak§, and Scott F. Dowell¶Comments to Author 
Author affiliations: *Queen Sirikit National Institute of Child Health, Bangkok, Thailand; †Ministry of Public Health, Nonthaburi, Thailand; ‡Siriraj Hospital, Bangkok, Thailand; §Thammasat University Hospital, Bangkok, Thailand; ¶International Emerging Infections Program, Nonthaburi, Thailand

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Table 2

Characteristics and clinical findings of confirmed avian influenza A (H5N1) cases in Thailand, 2004*

Characteristics Patient no.
%
1 2 3 4 5 6 7 8 9 10 11 12
Age (y), sex 2, M 27, F 31, M 46, F 5, M 6, M 6, M 6, M 7, M 13, M 39, F 58, F 67 (M)
Symptoms
Fever + + + + + + + + + + + + 100
Rhinorrhea + + + + 33
Cough + + + + + + + + + + + + 100
Sore throat + + + + + + + + + 75
Myalgia + + + + + 42
Dyspnea + + + + + + + + + + + + 100
Diarrhea + + + + + 42
Abdominal pain + + 17
Conjunctivitis 0
Vomiting + + + 25
Laboratory values
Hematocrit (vol%) 30 39 38 46 39 32 39 40 41 37 33 38
   Total leukocyte count 4,200 13,600 4,660 7,360 5,600 1,200 2,200 4,900 4,100 2,000 3,300 5,680
   Total lymphocyte count 2,646 3,400 513 2,429 2,296 624 638 1,763 1,435 580 660 454
   Platelet count (x103) 214 306 171 272 94 89 140 111 304 150 380 185
Treatment
Oseltamivir + + + + + + + 58
Corticosteroids + + + + + + + + 67
Outcome
ARDS + + + + + + + + + 75
Inotropic support + + + + + 42
Peak AST (U) 129 18 74 NA 70 790 175 280 120 34 394 NA
Peak ALT (U) 57 23 41 NA 47 150 43 50 52 47 106 NA
Peak BUN (mg/dL) NA 8 10.7 NA 12 NA 14 22 10 132 37 39
Peak creatinine (mg/dL) NA 0.8 1.07 NA 0.7 NA 1.7 1.1 0.7 8.1 3.6 2.3
Survival 
(day of death) + + + + – (13) – (20) – (18) – (8) – (29) – (16) – (13) – (8) 33

*M, male; f, female; +, yes, –, no, NA, not applicable; ARDS, acute respiratory distress syndrome; AST, aspartate aminotransferase; ALT, alanine aminotransferase; BUN, blood urea nitrogen.

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