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Volume 11, Number 4—April 2005

Research

Experimental Infection of Prairie Dogs with Monkeypox Virus

Shu-Yuan Xiao*, Elena Sbrana*, Douglas M. Watts*, Marina Siirin*, Amelia P.A. Travassos da Rosa*, and Robert B. Tesh*Comments to Author 
Author affiliations: *University of Texas Medical Branch, Galveston, Texas, USA

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Table 1

Results of virus titration of serial blood and throat swab samples taken from prairie dogs after experimental monkeypox infection

Day after infection Animal no.*
MPX-1
MPX-3
MPX-4
MPX-5
MPX-6
MPX-7
MPX-8
MPX-9
B TS B TS B TS B TS B TS B TS B TS B TS
1 0 NT 0 NT 0 NT 0 NT 0 NT 0 NT 0 NT 0 NT
2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
3 0 0 0 0 0 0 0 0.7 0 0 0 0 0 1.0 0 0
4 0 0 0 0 0 0 0 0.7 0 0 0 2.4 0 0.7 0 1.6
5 0 0 0.7 0.7 1.9 1.9 0 2.2 0 0 0 2.6 0 1.5 0 1.7
6 1.2† 1.4 1.7 1.5 3.9 3.2 0 3.2 0 2.4 0 1.4 0 1.2 0 1.4
7 2.4 3.0 2.3 2.5 5.4 4.2 0 3.6 0 1.9 0 2.7 0 2.0 0 2.0
8 2.5 3.2 3.5 1.7 D D 0 3.6 0 1.6 0 2.7 0 2.3 1.5 3.2
9 4.0 4.3 D D 1.4 4.6 1.6 2.7 1.4 2.6 3.4 3.5 1.2 4.5
10 5.3 5.1 1.0 4.8 3.5 3.0 2.1 3.7 4.4 2.5 3.6 5.0
11 D D 1.4 5.0 D D 1.9 3.9 4.0 4.4 3.8 5.1
12 1.2 5.1 2.3 4.7 4.4 4.7 4.3 5.2
13 2.4 5.1 2.0 3.5 4.0 5.1 D D
14 NT NT D D NT NT
15 4.5 4.4 4.0 5.0
16 NT 4.3 NT 5.0
17 NT 3.2 NT 5.2
18 NT 2.1 NT 5.0
19 NT 2.9 NT 4.8
20 NT 1.7 NT 4.2
21 NT 1.0 NT 4.0
22 NT 0 NT 2.9

*Animals MPX-1, MPX-3, and MPX-4 were infected intraperitoneally; animals MPX-5 to MPX-9 were infected intranasally.
†Indicates titer of monkeypox virus in sample; log10 PFU/mL of sample (blood [B] or throat swab diluent [TS]); 0, <100.7 PFU/mL; NT, not tested; D, animal dead.

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