Relative Fitness of Fluoroquinolone-resistant Streptococcus pneumoniae
Figure 3. . Percentage recovery units (PRUs: CFUs recovered from nasal wash or lung homogenate divided by CFUs originally used to infect mice and multiplied by 106) for competitive pneumonia infection with Streptococcus pneumoniae EF3030 and the Phe/Phe mutant (A), EF3030 and the Phe/Tyr mutant (B), and noncompetitive pneumonia with EF3030, Phe/Phe, and Phe/Tyr (C). Lines connect data from the same mouse. Bars indicate median PRUs. NP, nasopharynx. p values were calculated by the Wilcoxon matched-pairs signed-rank test (A and B) and the Mann-Whitney unpaired 2-tailed test (C).