Global Spread of Vancomycin-resistant Enterococcus faecium from Distinct Nosocomial Genetic Complex
Rob J.L. Willems* , Janetta Top*, Marga van Santen†, D. Ashley Robinson‡, Teresa M. Coque§, Fernando Baquero§, Hajo Grundmann†, and Marc J.M. Bonten*
Author affiliations: *University Medical Center Utrecht, Utrecht, the Netherlands; †National Institute for Public Health and the Environment, Bilthoven, the Netherlands,; ‡New York Medical College, Valhalla, New York, USA; §Hospital Ramon y Cajal, Madrid, Spain
Figure 3. . Sequence diversity versus allelic diversity. The average number of nucleotide (nt) differences in nonidentical alleles for all pairwise comparisons of the 178 Enterococcus faecium sequence types (STs), and the 15 STs belonging to complex-17 was calculated separately for allelic profiles that differ in 1–7 alleles. This computation shows no positive correlation between the number of nucleotide differences and allelic differences, which suggests that recombination has played an important role in the genetic diversification in E. faecium, including the STs that constitute complex-17.
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