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Volume 11, Number 6—June 2005

Research

Global Spread of Vancomycin-resistant Enterococcus faecium from Distinct Nosocomial Genetic Complex

Rob J.L. Willems*Comments to Author , Janetta Top*, Marga van Santen†, D. Ashley Robinson‡, Teresa M. Coque§, Fernando Baquero§, Hajo Grundmann†, and Marc J.M. Bonten*
Author affiliations: *University Medical Center Utrecht, Utrecht, the Netherlands; †National Institute for Public Health and the Environment, Bilthoven, the Netherlands,; ‡New York Medical College, Valhalla, New York, USA; §Hospital Ramon y Cajal, Madrid, Spain

Main Article

Table 1

Frequency of ampicillin and glycopeptide resistance, the presence of the pathogenicity island (PAI), and log odds of all complex-17 and non–complex-17

Epidemiologic source Genetic and phenotypic features*
Complex-17
Other†
Complex-17
Other†
Complex-17
Other†
Complex-17‡ Other†‡ Log odds§
AmR AmS AmR AmS PAI+ PAI– PAI+ PAI– VanR VanS VanR VanS
Animal surveillance (n = 96), % 1 0 2 93 0 1 0 94 0 1 43 52 1 [1] 95 [99] –4.55
Community surveillance (n = 57), % 0 0 1 46 3 0 0 47 3 0 17 37 3 [5] 54 [95] –2.89
Hospital surveillance (n = 64), % 14 0 7 40 7 8 0 49 13 2 32 17 15 [23] 49 [77] –1.18
Clinical (n = 162), % 85 2 13 47 47 47 4 57 21 73 22 45 95 [59] 67 [51 0.35
Hospital outbreak (n = 32), % 26 0 3 1 20 6 3 1 24 4 4 0 28 [88] 4 [12] 1.95

*Ampicillin resistant (AmR) or susceptible (AmS) not determined in 30 isolates, PAI present (PAI+) or absent (PA–) not determined in 17 isolates, vancomycin resistant (VanR) or susceptible (VanS) not determined in 1 isolate.
†Not belonging to complex-17.
‡Numbers in brackets refer to the percentage of isolates that belong to the complex.
§The natural logarithm of the proportion of samples from an epidemiologic source belonging to complex-17.

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