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Volume 11, Number 6—June 2005

Dispatch

Macrolide- and Telithromycin-resistant Streptococcus pyogenes, Belgium, 1999–20031

Surbhi Malhotra-Kumar*Comments to Author , Christine Lammens*, Sabine Chapelle*, Monique Wijdooghe*, Jasper Piessens*, Koen Van Herck*, and Herman Goossens*
Author affiliations: *University of Antwerp, Antwerp, Belgium

Main Article

Table A2

Temporal changes in pulsed-field gel electrophoresis (PFGE) and emm type distribution among 3 macrolide-resistant Streptococcus pyogenes phenotypes

Macrolide-resistant phenotype Emm type PFGE cluster* Frequency (n=506) No. (%) of macrolide-resistant S. pyogenes
1999 (n=81) 2000 (n=41) 2001 (n=73) 2002 (n=215) 2003 (n=96)
cMLS emm22 1 70 45 (56) 7 (17) 9 (12) 7 (3) 2 (2)
1057 1 1 (0.4)
emm4 10 9 9 (12)
11 8 3 (4) 2 (3) 2 (1) 1 (1)
1002 1 1 (1)
1009 2 2 (5)
emm76 32 1 1 (1)
emm2 new2 1 1 (2)
emm28 4 45 4 (5) 15 (7) 26 (27)
emm11 23 28 1 (1) 6 (3) 21 (22)
emm75 15 1 1 (1)
emm6 5 1 1 (1)
emm12 6 1 1 (1)
57 11 8 (4) 3 (3)
emm77 10 6 6 (3)
NT† 2 3 3 (1)
49 12 12 (6)
64 4 4 (2)
65 1 1 (0.4)
69 2 2 (1)
70 1 1 (0.4)
M emm1 1001 128 7 (9) 12 (29) 23 (32) 80 (37) 6 (6)
1022 2 2 (2)
3 1 1 (1)
emm12 6 1 1 (0.4)
1011 10 4 (5) 2 (5) 3 (4) 1 (0.4)
1025 10 3 (4) 2 (1) 5 (5)
1026 2 2 (2)
1027 1 1 (1)
1030 2 1 (2) 1 (0.4)
1035 9 1 (1) 4 (2) 4 (4)
1044 1 1 (0.4)
1047 2 2 (1)
emm2 18 1 1 (1)
1038 1 1 (1)
new 3 1 1(1)
1042 1 1 (0.4)
1034 1 1 (1)
1049 1 1 (0.4)
emm4 1002 28 2 (2.5) 2 (5) 7 (10) 7 (3) 10 (10)
1007 2 2 (5)
1008 1 1 (1)
1009 1 1 (2)
1010 11 1 (1) 3 (7) 2 (3) 2 (1) 3 (3)
1019 1 1 (1)
1021 2 2 (2)
1043 1 1 (0.4)
1044 3 3 (3)
1054 2 2 (1)
1059 1 1 (0.4)
emm77 1028 4 4 (10)
9 2 1 (2) 1 (1)
10 3 3 (1)
emm75 1036 1 1 (1)
1060 1 1 (0.4)
emm33 1046 2 2 (1)
1052 2 2 (1)
emm78 1042 1 1 (0.4)
emm28 1033 1 1 (1)
emm9 1042 2 2 (2)
emm60 8 1 1 (1)
NT 42 1 1 (1)
1018 1 1 (2)
62 3 3 (1)
71 1 1 (0.4)
1005 2 2 (1)
1012 2 2 (1)
1033 2 2 (1)
1042 1 1 (0.4)
1043 3 3 (1)
1044 3 3 (1)
1045 1 1 (0.4)
1049 3 3 (1)
1050 1 1 (0.4)
1051 1 1 (0.4)
1055 1 1 (0.4)
1058 1 1 (0.4)
1061 2 2 (2)
83 1 1 (1)
26 1 1 (1)
iMLS emm1 1031 1 1 (2)
emm22 1 2 2 (3)
emm4 10 1 1 (1)
emm9 61 1 1 (1)
emm77 9 2 1 (1) 1 (0.4)
10 1 1 (0.4)
50 2 1 (1) 1 (0.4)
emm12 57 1 1 (0.4)
emm18 1048 1 1 (0.4)
emm89 77 1 1 (1)
NT new 1 1 1 (2)
63 1 1 (0.4)
49 3 3 (3)

*PFGE profile numbers from 1-100 designate restriction with SmaI and above 1,000 restriction profiles generated with SfiI.
†NT, non-typeable.

Main Article

1A preliminary account of this work was presented at the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy, October 30–November 2, 2004, Washington DC, USA.

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