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Volume 11, Number 6—June 2005

Research

Trypanosomiasis Relapse after Melarsoprol Therapy, Democratic Republic of Congo, 1982–2001

Jacques Pépin*Comments to Author  and Bokelo Mpia†
Author affiliations: *Centre for International Health and Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada; †Nioki Hospital, Nioki, Democratic Republic of Congo

Main Article

Table 1

Demographic and clinical characteristics of all patients with Trypanosoma brucei gambiense trypanosomiasis treated in Nioki hospital, 1982–2001*

Characteristic 1982–1985 (%)
(n = 1,074) 1986–1989 (%)
(n = 889) 1990–1993 (%)
(n = 535) 1994–1997 (%)
(n = 447) 1998–2001 (%)
(n = 374) p value
Sex <0.001
Females 669 (62) 472 (53) 283 (53) 217 (49) 161 (43)
Males 405 417 252 230 213
Age (y) <0.001
≤14 239 (25) 178 (20) 91 (18) 69 (15) 63 (17)
15–49 569 (60) 600 (68) 353 (69) 330 (74) 267 (71)
≥50 146 (15) 105 (12) 66 (13%) 47 (11) 44 (12)
Area of residence <0.001
Nioki town 152 (15) 212 (24) 150 (28) 105 (23) 114 (30)
Mfimi River 585 (58) 329 (37) 151 (28) 129 (29) 119 (32)
Molibampe River 78 (8) 79 (9) 60 (11) 72 (16) 49 (13)
Baboma/Basengele 137 (14) 146 (16) 58 (11) 62 (14) 43 (11)
Out of district 61 (6) 123 (14) 116 (22) 79 (18) 49 (13)
Trypanosomes in lymph node aspirate <0.001
Yes 624 (58) 415 (47) 180 (34) 160 (36) 130 (35)
No 450 474 355 287 244
Trypanosomes in blood <0.001
Yes 313 (29) 341 (38) 157 (29) 138 (31) 126 (34)
No 761 548 378 309 248
Trypanosomes in CSF <0.001
Yes 135 (13) 278 (31) 246 (46) 239 (53) 187 (50)
No 939 611 289 208 187
CSF leukocyte count (per mm3) <0.001
1–5 407 (38) 286 (32) 75 (14) 32 (7) 26 (7)
6–19 188 (18) 120 (13) 38 (7) 34 (8) 38 (10)
20–99 189 (18) 144 (16) 122 (23) 118 (26) 109 (29)
≥100 289 (27) 339 (38) 300 (56) 263 (59) 201 (54)
Median CSF leukocyte count (per mm3) 12 31 120 130 112 <0.001

*CSF, cerebrospinal fluid.

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