Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

Volume 11, Number 6—June 2005

Research

Trypanosomiasis Relapse after Melarsoprol Therapy, Democratic Republic of Congo, 1982–2001

Jacques Pépin*Comments to Author  and Bokelo Mpia†
Author affiliations: *Centre for International Health and Department of Microbiology and Infectious Diseases, University of Sherbrooke, Sherbrooke, Quebec, Canada; †Nioki Hospital, Nioki, Democratic Republic of Congo

Main Article

Table 3

Risk factors for relapses following treatment with melarsoprol (excluding patients who died during treatment)*

Relapses/total (%) Odds ratios (95% CI) Adjusted odds ratios (95% CI)
Sex
Females 55/1,091 (5.0) 1.00 1.00
Males 80/1,014 (7.9) 1.61 (1.13–2.30)† 1.57 (1.08–2.27)†
Age (y)
≤14 19/382 (5.0) 1.00
15–49 97/1,380 (7.0) 1.44 (0.87–2.39)
≥50 14/257 (5.4) 1.10 (0.54–2.24)
Year of diagnosis
1982–1985 31/553 (5.6) 1.00 1.00
1986–1989 35/512 (6.8) 1.24 (0.75–2.04) 0.83 (0.45–1.52)
1990–1993 18/398 (4.5) 0.80 (0.44–1.45) 0.47 (0.23–0.97)†
1994–1997 34/299 (11.4) 2.16 (1.30–3.59)† 0.82 (0.40–1.69)
1998–2001 17/343 (5.0) 0.88 (0.48–1.61) 0.31 (0.13–0.71)†
Area of residence
Nioki town 40/486 (8.2) 1.00 1.00
Mfimi River 62/783 (7.9) 0.96 (0.63–1.45) 1.04 (0.67–1.61)
Molibampe River 13/197 (6.6) 0.79 (0.41–1.51) 0.76 (0.39–1.48)
Baboma/Basengele 4/302 (1.3) 0.15 (0.05–0.42)‡ 0.14 (0.05–0.40)‡
Out of district 16/311 (5.1) 0.60 (0.33–1.10) 0.59 (0.32–1.10)
Trypanosomes in lymph node aspirate
No 77/1,217 (6.3) 1.00
Yes 58/888 (6.5) 1.03 (0.73–1.47)
Trypanosomes in CSF
No 62/1,233 (5.0) 1.00 1.00
Yes 73/872 (8.4) 1.73 (1.22–2.45)† 1.52 (1.02–2.27)†
CSF leukocyte count (per mm3)
1–5 1/94 (1.1) 0.23 (0.03–1.79)
6–19 15/341 (4.4) 1.00
20–99 39/572 (6.8) 1.59 (0.86–2.93)
≥100 80/1,098 (7.3) 1.71 (0.97–3.01)
Melarsoprol regimens
1 series of 3 injections 1/69 (1.4) 0.21 (0.03–1.53) 0.29 (0.04–2.18)
2 series of 3 injections 11/331 (3.3) 0.49 (0.26–0.93)† 0.47 (0.23–0.95)†
3 series of 3 injections 80/1,222 (6.5) 1.00 1.00
3 series of 4 injections 15/250 (6.0) 0.91 (0.52–1.61) 0.62 (0.30–1.26)
3 series of 3, incremental 16/68 (23.5) 4.39 (2.40–8.04) 4.68 (2.26–9.69)
10 daily injections 12/165 (7.3) 1.12 (0.60–2.10) 1.58 (0.74–3.38)
Prednisolone
No 33/643 (5.1) 1.00
Yes 102/1,462 (7.0) 1.39 (0.93–2.08)

*CI, confidence interval; CSF, cerebrospinal fluid. †p<0.05. ‡p<0.001.

Main Article

TOP