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Volume 11, Number 6—June 2005

Dispatch

Erythromycin-nonsusceptible Streptococcus pneumoniae in Children, 1999–2001

M. Catherine McEllistrem*Comments to Author , Jennifer M. Adams*, Kathleen Shutt*, Laurie T. Sanza†, Richard R. Facklam‡, Cynthia G. Whitney‡, James H. Jorgensen§, and Lee H. Harrison*†
Author affiliations: *University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania, USA; †Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA; ‡Centers for Disease Control and Prevention, Atlanta, Georgia, USA; §University of Texas Health Science Center, San Antonio, Texas, USA

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Table

Annual rates of erythromycin-nonsusceptible pneumococcocal disease*

Age group Disease 1995
1999
2001
1995 vs. 1999
1999 vs. 2001
No. of cases Rate No. of cases Rate No. of cases Rate Change in rate (%) p value Change in rate (%) p value
All All invasive 683 28.1 762 31.1 599 23.6 10.7 0.05 -24.1 <0.01
Erythromycin-nonsusceptible S. pneumoniae 26 1.4 71 3.2 77 3.2 125.3 <0.01 -0.7 1.0
mefE 12 0.7 51 2.3 65 2.7 250.7 <0.01 16.7 0.4
England14-9, mefE 5 0.3 19 0.9 23 1.0 213.6 0.01 10.8 0.8
<5 y All invasive 135 76.7 146 89.3 63 38.1 16.4 0.2 -57.4 <0.01
Erythromycin-nonsusceptible S. pneumoniae 8 6.1 23 15.6 11 7.2 153.5 0.01 -53.6 0.03
mefE 3 2.3 18 12.2 9 5.9 429 <0.01 -51.5 0.07
England14-9, mefE 1 0.8 11 7.4 4 2.6 870 <0.01 -64.7 0.05
≥5 y All invasive 548 24.3 616 26.9 536 22.6 10.8 0.08 -16.1 <0.01
Erythromycin-nonsusceptible S. pneumoniae 18 1.1 48 2.3 66 2.9 119 <0.01 25.2 0.2
mefE 9 0.5 33 1.6 56 2.5 201.2 <0.01 54.6 0.04
England14-9, mefE 4 0.2 8 0.4 19 0.8 64.3 0.4 116.3 0.06

*Rate calculations: For cases where an isolate was not available, erythromycin susceptibility, presence of mefE gene, and serotype were assumed to be similar to those for which an isolate was available. For each disease category, rates >2 for ≥1 year in any age group are included in the table.

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