Volume 11, Number 6—June 2005
Rifampin-resistant Meningococcal Disease
|Strain||Description||Rifampin MIC (μg/mL)||Amino acid change*|
|MDH02-2342||Sporadic rifampin-susceptible serogroup C case isolate||0.004†||None (WT)|
|MDH02-2271||Sporadic rifampin-susceptible serogroup B case isolate||<0.002†||None (WT)|
|MDH97-498||Isolate from sporadic rifampin-resistant serogroup B case in 1996||>4,† >32‡||His552Tyr§|
|MDH02-2398||First sibling's isolate: rifampin susceptible, serogroup C||0.008†||None (WT)|
|MDH02-2408||Second sibling's isolate: rifampin resistant, serogroup C||>1,† >32‡||Ser548Phe§|
†Determined by broth microdilution.
‡Determined by Etest.
§Numbering based on the entire N. meningitidis rpoB gene (GenBank accession no. Z54353). Accession numbers of isolate sequences submitted to GenBank: MDH02-2342 (AY746965), MDH02-2271 (AY746964), MDH97-498 (AY746963), MDH02-2398 (AY746966), MDH02-2408 (AY746967).
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