Emergence and Spread of Streptococcus pneumoniae with erm(B) and mef(A) Resistance
David J. Farrell* , Stephen G. Jenkins†, Steven D. Brown‡, Manish Patel§, Bruce S. Lavin§, and Keith P. Klugman¶#
Author affiliations: *G.R. Micro Ltd, London, United Kingdom; †Mount Sinai School of Medicine, New York, New York, USA; ‡Clinical Microbiology Institute, Wilsonville, Oregon, USA; §sanofi-aventis, Bridgewater, New Jersey, USA; ¶Emory University, Atlanta, Georgia, USA; #University of the Witwatersrand, Johannesburg, South Africa
Figure. . Phylogenetic relationships of the 82 different sequence type variations found in 518 Streptococcus pneumoniae isolates with combined erm(B)- and mef(A)-mediated macrolide resistance collected during the PROTEKT global study (1999–2003, n = 366) and the PROTEKT US study (2000–2003, n = 152) compared with the 20 PMEN (Pneumococcal Molecular Epidemiology Network ) clones.
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