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Volume 11, Number 6—June 2005

Research

Emergence and Spread of Streptococcus pneumoniae with erm(B) and mef(A) Resistance

David J. Farrell*Comments to Author , Stephen G. Jenkins†, Steven D. Brown‡, Manish Patel§, Bruce S. Lavin§, and Keith P. Klugman¶#
Author affiliations: *G.R. Micro Ltd, London, United Kingdom; †Mount Sinai School of Medicine, New York, New York, USA; ‡Clinical Microbiology Institute, Wilsonville, Oregon, USA; §sanofi-aventis, Bridgewater, New Jersey, USA; ¶Emory University, Atlanta, Georgia, USA; #University of the Witwatersrand, Johannesburg, South Africa

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Table 1

Geographic distribution by year of Streptococcus pneumoniae collected from years 1 to 3 of the PROTEKT US study with both erm(B)- and mef(A)-encoded macrolide resistance among genotyped erythromycin-resistant isolates

US region* No. erm(B)+mef(A)–positive/no. erythromycin-resistant (%)
Year 1 Year 2 Year 3 Years 1–3 combined
North-Central 121/667 (18.1) 117/626 (18.7) 176/735 (23.9) 414/2,028 (20.4)
Northeast 88/985 (8.9) 96/771 (12.5) 140/900 (15.6) 324/2,656 (12.2)
Northwest 8/98 (8.2) 18/119 (15.1) 26/125 (20.8) 52/342 (15.2)
South-Central 23/561 (4.1) 36/463 (7.8) 80/667 (12.0) 139/1,691 (8.2)
Southeast 29/427 (6.8) 31/481 (6.4) 49/475 (10.3) 109/1,383 (7.9)
Southwest 35/395 (8.9) 37/333 (11.1) 49/275 (17.8) 121/1,003 (12.1)
Total 304/3,133 (9.7) 335/2,793 (12.0) 520/3,177 (16.4) 1,159/9,103 (12.7)

*North-Central = Illinois, Iowa, Kansas, Minnesota, Missouri, Nebraska, North Dakota, South Dakota, Wisconsin; Northeast = Connecticut, Delaware, Indiana, Maryland, Massachusetts, Michigan, New Jersey, New York, Ohio, Pennsylvania, Rhode Island, Vermont, Washington DC; Northwest = Alaska, Idaho, Montana, Oregon, Washington, Wyoming; South-Central = Alabama, Arkansas, Louisiana, Oklahoma, Tennessee, Texas; Southeast = Florida, Georgia, Kentucky, North Carolina, Puerto Rico, South Carolina, Virginia, West Virginia; Southwest = Arizona, California, Colorado, Nevada, New Mexico, Utah.

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