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Volume 11, Number 6—June 2005

Research

Emergence and Spread of Streptococcus pneumoniae with erm(B) and mef(A) Resistance

David J. Farrell*Comments to Author , Stephen G. Jenkins†, Steven D. Brown‡, Manish Patel§, Bruce S. Lavin§, and Keith P. Klugman¶#
Author affiliations: *G.R. Micro Ltd, London, United Kingdom; †Mount Sinai School of Medicine, New York, New York, USA; ‡Clinical Microbiology Institute, Wilsonville, Oregon, USA; §sanofi-aventis, Bridgewater, New Jersey, USA; ¶Emory University, Atlanta, Georgia, USA; #University of the Witwatersrand, Johannesburg, South Africa

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Table 2

Proportion of erythromycin-resistant Streptococcus pneumoniae isolates collected from years 1 to 3 of the PROTEKT US study with the dual mef(A)+erm(B) genotype according to patient age

Patient age (y) No. erm(B)+mef(A)–positive/no. erythromycin-resistant (%)
Year 1 Year 2 Year 3
0–2 88/825 (10.7) 118/640 (18.4) 170/710 (23.9)
3–14 52/388 (13.4) 47/365 (12.9) 84/409 (20.5)
15–64 98/1,106 (8.9) 95/972 (9.8) 151/1,173 (12.9)
>64 58/727 (8.0) 70/755 (9.3) 98/794 (12.3)
Not specified
8/87 (9.2)
5/61 (8.2)
17/91 (18.7)
Total 304/3,133 (9.7) 335/2,793 (12.0) 520/3,177 (16.4)

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