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Volume 11, Number 6—June 2005

Research

Emergence and Spread of Streptococcus pneumoniae with erm(B) and mef(A) Resistance

David J. Farrell*Comments to Author , Stephen G. Jenkins†, Steven D. Brown‡, Manish Patel§, Bruce S. Lavin§, and Keith P. Klugman¶#
Author affiliations: *G.R. Micro Ltd, London, United Kingdom; †Mount Sinai School of Medicine, New York, New York, USA; ‡Clinical Microbiology Institute, Wilsonville, Oregon, USA; §sanofi-aventis, Bridgewater, New Jersey, USA; ¶Emory University, Atlanta, Georgia, USA; #University of the Witwatersrand, Johannesburg, South Africa

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Table 5

Distributions of sequence types and serotypes of 518 dual erm(B)+mef(A) erythromycin-resistant Streptococcus pneumoniae isolates collected during the PROTEKT global study (1999–2003, n = 366) and the PROTEKT US study (2000–2003, n = 152)*

Clonal complex (n) PMEN clone designation Sequence types (n) Serotypes (n)
CC 271 (446) Taiwan19F-14 236 (48)†, 257 (1), 271 (218), 283 (4), 320 (93), 1396 (6), 1407 (1), 1408 (2), 1409 (4), 1410 (3), 1411 (1), 1412 (3), 1413 (1), 1414 (1), 1415 (1), 1416 (2), 1417 (1),1418 (11), 1419 (4), 1420 (1), 1421 (3), 1422 (1), 1423 (1), 1425 (1), 1428 (3), 1429 (2), 1430 (1), 1431 (1), 1432 (3), 1433 (2), 1434 (1), 1449 (1), 1451 (5), 1453 (1), 1455 (2), 1457 (1), 1458 (1), 1459 (1), 1460 (1), 1461 (2), 1462 (1), 1463 (1), 1464 (2), 1465 (1), 1466 (1) 14 (3), 19A (66), 19F (376), NT (1)
CC 242 (25) Taiwan23F-15 242 (9), 880 (1), 1435 (2), 1436 (1), 1441 (1), 1442 (1), 1443 (1), 1444 (7), 1445 (2) 23F (25)
CC 81 (12) Spain23F-1 81 (10), 1450 (1), 1456 (1) 14 (1), 19F (3), 23F (5), 6A (1), NT (2)
Singletons 13 (4), 66 (1), 87 (2), 90 (2), 451 (2), 1424 (3), 1426 (8), 1427 (1), 1437 (2), 1438 (1), 1439 (1), 1440 (1), 1446 (1), 1447 (1), 1448 (1), 1452 (1), 1454 (1), 1467 (2) 14 (4), 34(1), 16F (1), 19A (9), 19F (6), 23F (2), 35B (2), 6A (1), 6B (7), 7F (1), 9N (1)

*PMEN, Pneumococcal Molecular Epidemiology Network; NT, nontypeable.
†Sequence type 236 was previously described as CC 236 by Ko and Song (22) but is described as CC 271 in this study based on BURST analysis.

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