TY - JOUR AU - Miller, Martha AU - Obert, Caroline AU - Gao, Geli AU - Daw, Najat AU - Flynn, Patricia AU - Tuomanen, Elaine T1 - Cephalosporin-resistant Pneumococci and Sickle Cell Disease T2 - Emerging Infectious Disease journal PY - 2005 VL - 11 IS - 8 SP - 1192 SN - 1080-6059 AB - Sickle cell anemia patients have 600 times the risk for invasive pneumococcal disease than their healthy peers. High-level cephalosporin resistance was described in the 1990s in healthy children from Tennessee, but its prevalence in sickle cell disease patients is unknown. Pneumococcal isolates from sickle cell disease patients from Tennessee were subjected to multilocus sequence typing to characterize antimicrobial drug–resistant strains. Twenty-one percent of strains were resistant to cefotaxime and penicillin. Of the 14 cephalosporin-resistant strains, 9 were sequence types previously described as highly cephalosporin resistant, while resistance was found for the first time in 3 clones: Maryland6B, ST660, and a novel clone, ST1753. High-level cephalosporin resistance exists in more settings than initially recognized, and its high prevalence in sickle cell disease patients may decrease the efficacy of third-generation cephalosporins in invasive pneumococcal disease. KW - Keywords: infectious diseases KW - Antibiotic resistance KW - multi-drug resistance KW - anemia KW - sickle cell KW - United States DO - 10.3201/eid1108.050152 UR - https://wwwnc.cdc.gov/eid/article/11/8/05-0152_article ER - End of Reference