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Volume 11, Number 8—August 2005

Research

Influenza A (H3N2) Outbreak, Nepal

Luke T. Daum*†Comments to Author , Michael W. Shaw‡, Alexander I. Klimov‡, Linda C. Canas*, Elizabeth A. Macias*, Debra Niemeyer*, James P. Chambers†, Robert Renthal†, Sanjaya K. Shrestha§, Ramesh P. Acharya¶, Shankar P. Huzdar¶, Nirmal Rimal¶, Khin S. Myint#, and Philip Gould*
Author affiliations: *Air Force Institute for Operational Health, Brooks City Base, San Antonio, Texas; †University of Texas, San Antonio, Texas; ‡Centers for Disease Control and Prevention, Atlanta, Georgia; §Walter Reed/Armed Forces Research Institute of Medical Sciences Research Unit-Nepal, Kathmandu, Nepal; ¶Association of Medical Doctors of Asia-Nepal, Kathmandu, Nepal; #US Army Medical Component of the Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand

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Table 1

Hemagglutination inhibition (HI) reciprocal titers of influenza A (H3N2) viruses with ferret antisera*

Strain designation Reference ferret antisera
PAN/2007 KO/770 WY/03 TX/40 OK/8 WEL/01 Date collected
Reference antigens
A/Panama/2007/99 2,560 160 640 320 640 160 7/12/99
A/Korea/770/2002† 80 640 1,280 640 640 320 12/2/02
A/WyomingG/03/2003 640 320 1,280 1,280 1,280 320 2/13/03
A/Texas/40/2003 640 1,280 1,280 2,560 1,280 640 10/2/03
A/Oklahoma/8/2004 160 1,280 1,280 2,560 1,280 640 12/8/03
A/Wellington/1/2004 160 320 320 640 320 640 1/26/04
Test antigens
A/Nepal/1679/04 40 160 1,280 640 2,560 320 7/2/04
A/Nepal/1685/04 40 320 1,280 640 2,560 320 7/2/04
A/Nepal/1670/04 10 160 1,280 320 1,280 320 7/2/04
A/Nepal/1659/04 10 320 640 320 1,280 160 7/2/04
A/Nepal/1660/04 10 160 640 320 2,560 160 7/2/04
A/Nepal/1680/04 20 320 320 320 1,280 160 7/2/04
A/Nepal/1672/04 10 160 320 160 1,280 160 7/2/04
A/Nepal/1678/04 40 160 320 160 1,280 160 7/2/04
A/Nepal/1694/04 10 160 320 160 2,560 160 7/3/04

*Test antigens are considered antigenically different from the reference strain if HI titers show a 4-fold difference.
†A/Korea/770/2002 is antigenically equivalent to the A/Fujian/411/02 vaccine strain.

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