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Volume 11, Number 8—August 2005

Research

Influenza A (H3N2) Outbreak, Nepal

Luke T. Daum*†Comments to Author , Michael Shaw‡, Alexander I. Klimov‡, Linda C. Canas*, Elizabeth A. Macias*, Debra Niemeyer*, James P. Chambers†, Robert Renthal†, Sanjaya K. Shrestha§, Ramesh P. Acharya¶, Shankar P. Huzdar¶, Nirmal Rimal¶, Khin S. Myint#, and Philip Gould*
Author affiliations: *Air Force Institute for Operational Health, Brooks City Base, San Antonio, Texas; †University of Texas, San Antonio, Texas; ‡Centers for Disease Control and Prevention, Atlanta, Georgia; §Walter Reed/Armed Forces Research Institute of Medical Sciences Research Unit-Nepal, Kathmandu, Nepal; ¶Association of Medical Doctors of Asia-Nepal, Kathmandu, Nepal; #US Army Medical Component of the Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand

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Table 2

Unique hemagglutinin amino acid substitutions from influenza virus isolates obtained during July 2004 influenza outbreak in southeast Nepal compared with 5 vaccine strains*

Virus strain Amino acid position
145
Glycosylation site adjacent to antibody site A 155
Fujian-like lineage amino acid substitution 156
Fujian-like lineage amino acid substitution 189
Antibody site B 226
Antibody site D 227
Antibody site D
A/Nepal Consensus/04† N T H N I P
A/Fujian/411/02 K T H S V S
A/Wyoming/3/03 K T H S I S
A/Wellington/1/04 K T H N V P
A/California/7/04 N T H N I P
A/Panama/2007/99 K H Q S V S

*N, asparagine; T, threonine; H, histidine; I, isoleucine; P, proline; K, lysine; S, serine; V, valine; Q, glutamine.
†Consensus sequence derived from a multiple sequence protein alignment of 26 HA1 hemagglutinin sequences from Nepal.

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