Volume 11, Number 8—August 2005
Research
Influenza A (H3N2) Outbreak, Nepal
Luke T. Daum*†
, Michael W. Shaw‡, Alexander I. Klimov‡, Linda C. Canas*, Elizabeth A. Macias*, Debra Niemeyer*, James P. Chambers†, Robert Renthal†, Sanjaya K. Shrestha§, Ramesh P. Acharya¶, Shankar P. Huzdar¶, Nirmal Rimal¶, Khin S. Myint#, and Philip Gould*
, Michael W. Shaw‡, Alexander I. Klimov‡, Linda C. Canas*, Elizabeth A. Macias*, Debra Niemeyer*, James P. Chambers†, Robert Renthal†, Sanjaya K. Shrestha§, Ramesh P. Acharya¶, Shankar P. Huzdar¶, Nirmal Rimal¶, Khin S. Myint#, and Philip Gould*Table 2
Unique hemagglutinin amino acid substitutions from influenza virus isolates obtained during July 2004 influenza outbreak in southeast Nepal compared with 5 vaccine strains*
| Virus strain | Amino acid position |
|||||
|---|---|---|---|---|---|---|
| 145 Glycosylation site adjacent to antibody site A | 155 Fujian-like lineage amino acid substitution | 156 Fujian-like lineage amino acid substitution | 189 Antibody site B | 226 Antibody site D | 227 Antibody site D | |
| A/Nepal Consensus/04† | N | T | H | N | I | P |
| A/Fujian/411/02 | K | T | H | S | V | S |
| A/Wyoming/3/03 | K | T | H | S | I | S |
| A/Wellington/1/04 | K | T | H | N | V | P |
| A/California/7/04 | N | T | H | N | I | P |
| A/Panama/2007/99 | K | H | Q | S | V | S |
*N, asparagine; T, threonine; H, histidine; I, isoleucine; P, proline; K, lysine; S, serine; V, valine; Q, glutamine.
†Consensus sequence derived from a multiple sequence protein alignment of 26 HA1 hemagglutinin sequences from Nepal.
