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Volume 11, Number 9—September 2005
Research

Fluoroquinolone-resistant Escherichia coli, Indonesia

Kuntaman Kuntaman*1, Endang Sri Lestari†1, Juliëtte A. Severin‡1, Irma M. Kershof‡, Ni Made Mertaniasih*, Marijam Purwanta*, Usman Hadi*, James R. Johnson§, Alex van Belkum‡Comments to Author , Henri A. Verbrugh‡, on behalf of the Antimicrobial Resistance in IndonesiaPrevalence and Prevention study group
Author affiliations: *Airlangga University, Surabaya, Indonesia; †Diponegoro University, Semarang, Indonesia; ‡Erasmus Medical Center, Rotterdam, the Netherlands; §Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota, USA

Main Article

Table 1

Distribution of phylogenetic groups and virulence factors*

Group or factor All isolates (n = 396) FQ-susceptible (n = 200) FQ-resistant (n = 196) p values
A 215 (54) 103 (52) 112 (57) NS
B1 102 (26) 59 (30) 43 (22) NS
B2 17 (4) 15 (8) 2 (1) 0.001
D 62 (16) 23 (12) 39 (20) 0.02
papA 28 (7) 27 (14) 1 (1) <0.001
papC 29 (7) 28 (14) 1 (1) <0.001
sfa/focDE 8 (2) 8 (4) 0 0.007
afa/draBC 11 (3) 11 (6) 0 0.001
iutA 131 (33) 61 (31) 70 (36) NS
hlyD 20 (5) 20 (10) 0 <0.001
kpsM II 56 (14) 54 (27) 2 (1) <0.001
ExPEC 44 (11) 40 (20) 4 (2) <0.001

*FQ, fluoroquinolone; ExPEC, extraintestinal pathogenic Escherichia coli; NS, not significant. Screening for ExPEC was performed for 199 FQ-susceptible and 195 FQ-resistant isolates. Data are no. (%) of isolates.

Main Article

1The first 3 authors contributed equally to this manuscript.

2Widjoseno Gardjito, Erni P. Kolopaking, Djoko Roeshadi, Eddy Rahardjo, Hari Parathon, Kuntaman Kuntaman, Ni Made Mertaniasih, Nun Zairina, Endang Isbandiati, Mariyatul Qibtiyah, Marijam Purwanta, Usman Hadi, Ariawan Soejoenoes, Budi Riyanto, Hendro Wahyono, Musrichan Adhisaputro, Bambang Triwara, Endang Sri Lestari, Bambang Wibowo, Muchlis AU Sofro, Helmia Farida, Peterhans van den Broek, Offra Duerink, Henri Verbrugh, Inge Gyssens, and Monique Keuters.

3ExPEC: papEF (P fimbrial tip pilins); papG (P adhesin); papG alleles I, II, and III; sfaS (S fimbriae); focG (F1C fimbriae); iha (putative adhesin-siderophore); bmaE (M fimbriae); gafD (G fimbriae); F17a (F17a fimbriae); clpG (CS31A adhesin); afaE8 (afimbrial adhesin VIII); fimH (type 1 fimbriae); cnf1 (cytotoxic necrotizing factor); cdtB (cytolethal distending toxin); ireA (siderophore receptor); sat (secreted autotransporter toxin); astA (S-like enterotoxin); iroN (siderophore receptor); fyuA (yersiniabactin receptor); kpsM II, K1, and K2 (kpsM II variants; group 2 capsule); kpsM III (group 3 capsule); rfc (O4 lipopolysaccharide synthesis); cvaC (colicin V); traT (serum-resistance associated outer membrane protein); ibeA (invasion of brain endothelium); ompT (outer membrane protease T); iss (increased serum survival); usp (uropathogenic specific protein); malX (marker for pathogenicity-associated island from strain CFT073); and H7 fliC variant (flagellin).

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