Volume 12, Number 1—January 2006
Ocular Vaccinia Infection in Laboratory Worker, Philadelphia, 2004
|Patient and contact||Prior vaccination||Date of last vaccination||Anti-orthopoxvirus IgG present* (acute-phase serum, 10/04; convalescent-phase serum, 12/04)||Anti-orthopoxvirus IgM present† (acute-phase serum 10/04; convalescent-phase serum, 12/04)|
|Worker 1||Yes, 5×‡||1994||Yes/yes||No/no|
|Worker 2§||Yes, as child||12/01/04||Yes/yes||No/no|
|Worker 3§||Yes, as child||12/01/04||Yes/yes||No/no|
|Worker 4§||Yes, as child||12/01/04||No/no||No/no|
*Immunoglobulin G (IgG) optical density cutoff value (COV) = 0.214408; –, not performed.
†IgM optical density COV = 0.015763.
‡The last vaccination was ≈10 years before this incident.
§Three laboratory workers who also manipulated vaccinia were vaccinated 1 week before the convalescent-phase blood sample was drawn (workers 2, 3, and 4). All 3 had been vaccinated as children; workers 2 and 3 had orthopoxvirus-reactive IgG levels present above the COV. Worker 4 did not have IgG levels above the COV either before or after her recent vaccination.
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