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Volume 12, Number 10—October 2006

Dispatch

Fourth Human Parechovirus Serotype

Kimberley S.M. Benschop*Comments to Author , Janke Schinkel*, Manon E. Luken†, Peter J.M. van den Broek†, Matthias F.C. Beersma‡, Negassi Menelik§, Hetty W.M. van Eijk*, Hans L. Zaaijer*, Christina M.J.E. VandenBroucke-Grauls*, Marcel G.H.M. Beld*, and Katja C. Wolthers*
Author affiliations: *Academic Medical Center, Amsterdam, the Netherlands; †Primagen, Amsterdam, the Netherlands; ‡Leiden University Medical Center, Leiden, the Netherlands; §BovenIJ Ziekenhuis, Amsterdam, the Netherlands

Main Article

Table 1

Amino acid identity matrix of all known human parechovirus (HPeV) full-length sequences*

Target HPeV1 (H) HPeV2 (W) HPeV2 (CT) HPeV3 (A308) HPeV3 (Can)
ORF
K251176-02 88.7 86.9 90.1 89.1 89.3
HPeV1 (H) 88.6 88.1 87.2 87.3
HPeV2 (W) 85.8 85.1 85.0
HPeV2 (CT) 86.7 86.9
HPeV3 (A308) 98.2
HPeV3 (Can)
P1
K251176-02 78.3 78.6 81.3 74.7 75.1
HPeV1 (H) 81.6 76.4 74.9 75.3
HPeV2 (W) 74.2 73.9 73.9
HPeV2 (CT) 73.0 73.5
HPeV3 (A308) 97.4
HPeV3 (Can)
P2-P3
K251176-02 94.3 91.5 94.9 97.0 97.1
HPeV1 (H) 92.4 94.5 93.8 93.9
HPeV2 (W) 92.2 91.2 91.1
HPeV2 (CT) 94.2 94.2
HPeV3 (A308) 98.6
HPeV3 (Can)

*Amino acid identities for the open reading frame (ORF), capsid region (P1), and nonstructural region (P2-P3) are based on p-distance models between K251176-02 (DQ315670) and the HPeV prototypes, HPeV1 (H) (Harris, S45208), HPeV2 (W) (Williamson, AJ005695), HPeV2 (CT) (CT86-6760, AF055846), HPeV3 (A308) (A308-99, AB084913), and HPeV3 (Can) (Can82853-01, AJ889918). The full-length sequence of K251176-02 was aligned with the HPeV prototypes by using ClustalW, included in the Vector NTI Advance 10 software package (Invitrogen, Carlsbad, CA, USA). Alignment was edited by using GeneDoc software (version 2.6.02). The matrix was constructed by using MEGA version 3.1. The 5´ untranslated region (UTR) and 3´ UTR are excluded from the analysis because the regions are noncoding.

*Amino acid identities for the open reading frame (ORF), capsid region (P1), and nonstructural region (P2-P3) are based on p-distance models between K251176-02 (DQ315670) and the HPeV prototypes, HPeV1 (H) (Harris, S45208), HPeV2 (W) (Williamson, AJ005695), HPeV2 (CT) (CT86-6760, AF055846), HPeV3 (A308) (A308-99, AB084913), and HPeV3 (Can) (Can82853-01, AJ889918). The full-length sequence of K251176-02 was aligned with the HPeV prototypes by using ClustalW, included in the Vector NTI Advance 10 software package (Invitrogen, Carlsbad, CA, USA). Alignment was edited by using GeneDoc software (version 2.6.02). The matrix was constructed by using MEGA version 3.1. The 5´ untranslated region (UTR) and 3´ UTR are excluded from the analysis because the regions are noncoding.

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