Volume 12, Number 10—October 2006
Research
Active Surveillance of Candidemia, Australia
Sharon Chen*
, Monica Slavin†, Quoc Nguyen‡, Deborah Marriott‡, E. Geoffrey Playford§, David Ellis¶, Tania C. Sorrell*#, and the Australian Candidemia Study
, Monica Slavin†, Quoc Nguyen‡, Deborah Marriott‡, E. Geoffrey Playford§, David Ellis¶, Tania C. Sorrell*#, and the Australian Candidemia Study
Table 3
Univariate predictors of death by candidemia 30 days after diagnosis, Australia, 2001–2004*
| Variable | Deaths, % (no./total) | Nondeaths, % (no./total) | p value |
|---|---|---|---|
| Age >65 y | 53.8 (127/236) | 28.4 (175/617) | <0.001 |
| Malignancy | 36 (85/236) | 33.2 (205/617) | 0.44 |
| Hematologic malignancy | 16.9 (40/236) | 16.5 (102/617) | 0.88 |
| Lymphoma | 8.1 (19/236) | 5.0 (31/617) | 0.09 |
| Surgery in past 30 days | 44.4 (104/234) | 41.2 (254/616) | 0.40 |
| VAD | 87.1 (203/233) | 82.2 (505/614) | 0.09 |
| Hyperalimentation | 44.2 (103/233) | 35.3 (217/615) | 0.02 |
| Hemodialysis | 16.7 (39/234) | 8.3 (51/615) | <0. 001 |
| Urinary catheter/drainage device | 69.2 (162/234) | 53 (325/613) | <0.001 |
| Trauma/burns | 1.7 (4/234) | 5.8 (36/616) | 0.01 |
| Corticosteroid therapy | 44.9 (105/234) | 25.6 (158/616) | <0.001 |
| Antimicrobial drug use | 96.1 (224/233) | 85.5 (526/615) | <0.001 |
| Neutropenia | 20.9 (49/234) | 16.4 (101/614) | 0.126 |
| ICU stay | 34.3 (81/236) | 15.9 (98/617) | <0.001 |
| Sepsis present (day 0) | 87.6 (205/234) | 78.8 (484/614) | 0.003 |
| Treatment with antifungal agent† | 70.5 (165/234) | 91.7 (564/615) | <0.001 |
| VAD removal | 61.6 (98/159) | 82.5 (406/492) | <0.001 |
| Candida glabrata infection | 22.5 (53/236) | 12.6 (78/617) | <0.001 |
| Polycandidal infection | 3.8 (9/236) | 1.8 (11/617) | 0.08 |
| Inpatient healthcare-associated | 91.9 (218/237) | 85.7 (531/620) | 0.02 |
*VAD, vascular access device; ICU, intensive care unit.
†Includes all patients receiving >1 therapeutic dose of systemic antifungal agent(s) as advised by an infectious diseases physician.
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