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Volume 12, Number 11—November 2006
Letter

Resistance to Dihydroartemisinin

Sandrine Cojean*†, Véronique Hubert*, Jacques Le Bras*†‡, and Rémy Durand*‡§Comments to Author 
Author affiliations: *Hôpital Bichat Claude Bernard, Assistance Publique–Hôpitaux de Paris, Paris, France; †Université Paris 5, Paris, France; ‡Hôpital Avicenne, Bobigny, France; §Université Paris 13, Bobigny, France

Main Article

Table

Polymorphism in PfATPase6 and G7 genes and in vitro susceptibility to dihydroartemisinin of 154 Plasmodium falciparum isolates*

Gene Predicted products Position Amino acid Nucleotide change No. isolates Dihydroartemisinin IC50 (nmol/L)
ATPase6 Sarcoplasmic reticulum calcium- transporting ATPases 769 S AGT 153 0.1–31.8
S→N AAT 1 0.83
263 L TTA 154 0.1–31.8
L→S TCA 0
243 H CAT 152 0.1–31.8
H→Y TAT 2 4.2; 6.4
G7 ABC transporter 1,390 Wild (AAT)4 69 0.1–25.9
Mutant (3-bp indel) (AAT)3 85 0.15–31.8

*PfATPase, Plasmodium falciparum adenosine triphosphatase; IC50, 50% inhibitory concentration.

*PfATPase, Plasmodium falciparum adenosine triphosphatase; IC50, 50% inhibitory concentration.

Main Article

Page created: October 17, 2011
Page updated: October 17, 2011
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