On the Question of Sporadic or Atypical Bovine Spongiform Encephalopathy and Creutzfeldt-Jakob Disease
Paul Brown* , Lisa M. McShane†, Gianluigi Zanusso‡, and Linda Detwiler§
Author affiliations: *Bethesda, Maryland, USA; †National Institutes of Health, Bethesda, Maryland, USA; ‡University of Verona, Verona, Italy,; §Virginia-Maryland Regional College of Veterinary Medicine, College Park, Maryland, USA
Figure 1. Distribution of ages at onset of illness in 500 cases of neuropathologically verified or experimentally transmitted sporadic Creutzfeldt-Jakob disease. Approximately 10% of cases occur in patients during the middle third (25–49 years) of a human lifespan, which corresponds to age in cattle of ≈7–13 years.
The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.