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Volume 12, Number 12—December 2006
Perspective

On the Question of Sporadic or Atypical Bovine Spongiform Encephalopathy and Creutzfeldt-Jakob Disease

Paul Brown*Comments to Author , Lisa M. McShane†, Gianluigi Zanusso‡, and Linda Detwiler§
Author affiliations: *Bethesda, Maryland, USA; †National Institutes of Health, Bethesda, Maryland, USA; ‡University of Verona, Verona, Italy,; §Virginia-Maryland Regional College of Veterinary Medicine, College Park, Maryland, USA

Main Article

Figure 5

Diagram of 2 possible informative trends in the incidence of bovine spongiform encephalopathy (BSE) and Creutzfeld-Jakob disease (CJD). The left panel shows the likely trends of typical BSE and variant CJD (vCJD). The right upper panel shows 1 possible pair of trends of atypical BSE and sporadic CJD (sCJD) that might occur in conjunction with the typical BSE/vCJD trends, and would be consistent with the interpretation that atypical BSE is not sporadic and is not related to sCJD. The right lower

Figure 5. Diagram of 2 possible informative trends in the incidence of bovine spongiform encephalopathy (BSE) and Creutzfeld-Jakob disease (CJD). The left panel shows the likely trends of typical BSE and variant CJD (vCJD). The right upper panel shows 1 possible pair of trends of atypical BSE and sporadic CJD (sCJD) that might occur in conjunction with the typical BSE/vCJD trends, and would be consistent with the interpretation that atypical BSE is not sporadic and is not related to sCJD. The right lower panel shows a second possible associated pair of trends consistent with the interpretation that atypical BSE is sporadic and might also be related to the type 2 M/V subset of apparently sCJD.

Main Article

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The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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