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Volume 12, Number 12—December 2006

Perspective

On the Question of Sporadic or Atypical Bovine Spongiform Encephalopathy and Creutzfeldt-Jakob Disease

Paul Brown*Comments to Author , Lisa M. McShane†, Gianluigi Zanusso‡, and Linda Detwiler§
Author affiliations: *Bethesda, Maryland, USA; †National Institutes of Health, Bethesda, Maryland, USA; ‡University of Verona, Verona, Italy,; §Virginia-Maryland Regional College of Veterinary Medicine, College Park, Maryland, USA

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Figure 5

Diagram of 2 possible informative trends in the incidence of bovine spongiform encephalopathy (BSE) and Creutzfeld-Jakob disease (CJD). The left panel shows the likely trends of typical BSE and variant CJD (vCJD). The right upper panel shows 1 possible pair of trends of atypical BSE and sporadic CJD (sCJD) that might occur in conjunction with the typical BSE/vCJD trends, and would be consistent with the interpretation that atypical BSE is not sporadic and is not related to sCJD. The right lower

Figure 5. Diagram of 2 possible informative trends in the incidence of bovine spongiform encephalopathy (BSE) and Creutzfeld-Jakob disease (CJD). The left panel shows the likely trends of typical BSE and variant CJD (vCJD). The right upper panel shows 1 possible pair of trends of atypical BSE and sporadic CJD (sCJD) that might occur in conjunction with the typical BSE/vCJD trends, and would be consistent with the interpretation that atypical BSE is not sporadic and is not related to sCJD. The right lower panel shows a second possible associated pair of trends consistent with the interpretation that atypical BSE is sporadic and might also be related to the type 2 M/V subset of apparently sCJD.

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