Volume 12, Number 12—December 2006
Perspective
On the Question of Sporadic or Atypical Bovine Spongiform Encephalopathy and Creutzfeldt-Jakob Disease
, Lisa M. McShane†, Gianluigi Zanusso‡, and Linda Detwiler§Table 2
Summary of atypical cases of bovine spongiform encephalopathy (BSE)
| Country | Age, y | Breed | Symptoms | Neuropathology | Western blot pattern* | |
|---|---|---|---|---|---|---|
| Spongiform changes | Immunohistochemistry | |||||
| Italy | 11 | Bruna Alpina | None | Mild | Plaques | L |
| 15 | Piemontese | None | Mild | Plaques | L | |
| Denmark | 14 | Charolais | None | NR | NR | L |
| Poland | 12 | Black-white breed | None | Present | Positive (no plaques) | L |
| Japan | 2 | Holstein | None | Absent | Negative | L1 |
| 14 | Japanese Black | Dystasia | Severe | Positive (no plaques) | H | |
| Belgium | 5.5 | East-Flemish | None | Absent | Negative | L1 |
| France | 10 | Cross breed | None | NR | NR | H |
| 15 | Prim Holstein | None | NR | NR | H | |
| 8 | Charolais | None | NR | NR | H | |
| The Netherlands | 13 | Black-white Holstein, Freisian | NR | Present | No plaques | H |
| Sweden | 12 | Mixed Charolais | Recumbent | NR | Positive (no plaques) | H1 |
| Switzerland | 19 | Zebu | Typical BSE | Typical BSE | Positive (no plaques) | H |
| Germany | 13 | Angus | NR | Absent | Positive (no plaques) | H |
| 15 | Holstein-Freisian | NR | Absent | Positive (no plaques) | L | |
| USA | 12 | Brahma cross | Falling | Absent | No plaques | H |
| 10 | Red crossbred | Recumbent | Absent | No plaques | H | |
| Canada | 16 | Charolais | Recumbent | NR | Positive (no plaques) | H
*L, lower molecular weight; H, higher molecular weight (the 2 major Western blot PrP glycopatterns that distinguish the strains from each other and from the pattern seen in typical BSE); NR, not reported. Only the Italian cows and Swiss zebu had full neuropathologic examinations (others were limited to examination of the obex). Details are not available for additional animals with both H and L strains in France and Poland. *L, lower molecular weight; H, higher molecular weight (the 2 major Western blot PrP glycopatterns that distinguish the strains from each other and from the pattern seen in typical BSE); NR, not reported. Only the Italian cows and Swiss zebu had full neuropathologic examinations (others were limited to examination of the obex). Details are not available for additional animals with both H and L strains in France and Poland. |
*L, lower molecular weight; H, higher molecular weight (the 2 major Western blot PrP glycopatterns that distinguish the strains from each other and from the pattern seen in typical BSE); NR, not reported. Only the Italian cows and Swiss zebu had full neuropathologic examinations (others were limited to examination of the obex). Details are not available for additional animals with both H and L strains in France and Poland.
