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Volume 12, Number 2—February 2006

Perspective

Detecting Hepatitis B Surface Antigen Mutants

Paul F. Coleman*Comments to Author 
Author affiliation: *Abbott Laboratories, Abbott Park, Illinois, USA

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Table 1

Detection of most common hepatitis B surface antigen (HBsAg) mutants by 9 commercial assays (29)*†

Assay configuration Ausria poly/poly Auszyme mono/mono IMx HBsAg mono/poly AxSYM HBsAg mono/poly PRISM HBsAg mono/poly ARCHITECT HBsAg mono/poly Commercial assay A mono/mono Commercial assay B mono/mono Commercial assay C poly/mono
HBsAg mutants
Wildtype + + + + + + + + + + + + + + + + + +
Thr126- Ser + + + + + + + + + + + + + + +
Gln129- His + + + + + + + + + + + + + + +
Met133- Leu + + + + + + + + + + + + + + + + + +
Asp144- Ala + + + + + + + + + + + + – + + + +
Gly145- Arg + + + + + + + + + + + + – – –
Thr126- Ser + Gly145- Arg + + + + + + + + + + + – – –
Pro142- Leu + Gly145- Arg + + + + + + + + + + + + – – –
Pro142- Ser + Gly145- Arg + + + + + + + + + + + + – – –
Asp144- Ala + Gly145- Arg + + + + + + + + + + + – – –

*All positive samples confirmed in their respective assays.
†+ +, equivalent detection to wild-type antigen; +, detection less than wild-type antigen; –, not detected.

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