Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

Volume 12, Number 2—February 2006

Perspective

Detecting Hepatitis B Surface Antigen Mutants

Paul F. Coleman*Comments to Author 
Author affiliation: *Abbott Laboratories, Abbott Park, Illinois, USA

Main Article

Table 2

Detection of hepatitis B surface antigen (HBsAg) mutants by 4 commercial assays (30)

Capture/detection Abbott AxSYM HBsAg mono/poly Bayer Centaur HBsAg mono/mono Ortho Vitros ECi HBsAg mono/mono Roche Elecsys HBsAg mono/mono
Recombinant samples (s/co) (s/co) (s/co) (s/co)
Wild-type 5.45 15.17 15.95 9.77
Thr126- Ser 4.74 20.17 12.50 8.64
Gln129- His 4.48 20.12 13.85 8.61
Met133- Leu 4.84 12.72 12.15 8.58
Asp144- Ala 3.65 6.47 0.12 6.55
Gly145- Arg 3.85 <0.10 0.06 0.56
Thr126- Ser + Gly145- Arg 3.36 <0.10 0.05 0.51
Pro142- Leu + Gly145- Arg 3.77 <0.10 0.05 0.55
Pro142- Ser + Gly145- Arg 4.08 <0.10 0.06 0.54
Asp144- Ala + Gly145- Arg 3.62 <0.10 0.06 0.52
Clinical samples
Gly145 - Arg 5.85 <0.10 0.40 0.70
Pro120-Gln/Thr-131Lys/Gly145-Arg 2.48 <0.10 0.14 0.62
Thr118-Val/Met133-Ile/Phe134-Asn/Pro142-Ser/Thr143-Leu/Gly145-Arg 17.60 <0.10 0.11 0.67
Thr115-Asn/Pro120-Leu/Met133-Ile/Phe134-His/Asp144-Val/Ser154-Pro 2.73 <0.10 0.10 0.58

Main Article

Top of Page

USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO